Avaliação da associação entre a Síndrome do Ovário Policístico, Desordens Temporomandibulares e fatores psicossociais em mulheres
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Ciências da saúdeAbstract
Frequentemente alterações hormonais locais e sistêmicas em mulheres são oriundas da Síndrome do Ovário Policístico (SOP) e parecem acarretar prejuízos às estruturas orofaciais, incluindo as desordens temporomandibulares (DTM) e suas repercussões psicossociais. O objetivo deste estudo foi avaliar a prevalência de DTM em mulheres com SOP, além de avaliar o impacto da dor orofacial na manifestação de sintomas físicos inespecíficos (incluindo e excluindo dor) e de depressão. Para isso, foi utilizado o Critério de Diagnóstico para Pesquisa das Desordens Temporomandibulares (Eixos I e II). A análise e a interpretação dos dados foram feitas utilizando o software SPSS for Windows 14.0 e organizados no formato de tabelas, e a estatística foi a inferencial, apresentadas com médias e porcentagens. Entre 37 mulheres com SOP, 56,8% apresentavam DTM, sendo 16,1% com manifestação miofascial. Os sintomas depressivos estavam presentes em 28,6% das pacientes com DTM e SOP em nível moderado e 33,3% em nível severo. Sintomas físicos inespecíficos de nível severo estavam presentes em 52,4% das mulheres com DTM e SOP. Fatores hormonais inerentes à SOP e os níveis acentuados de sintomas inespecíficos e de depressão parecem influenciar na cronificação álgica relacionada à DTM.Downloads
References
ALOISI, A.M. Gonadal hormones and sex differences in pain
reactivity. The Clinical journal of pain, v.19, n.3, p.168–174,
May-Jun. 2003.
AMANDUSSON, A.; BLOMQVIST, A. Estrogen receptors
can regulate pain sensitivity. Possible explanation of certain
chronic pain conditions. Lakartidningen, Stockholm, v.98, no.15,
p.1774–1778, Apr. 2001.
BARRY, J. A.; KUCZMIERCZYK, A. R.; HARDIMAN,
P. J. Anxiety and depression in polycystic ovary
syndrome: a systematic review and meta-analysis. Human
Reproduction, Oxford, v. 26, no.9, p.2442-2451, Sep. 2011.
BENDER, S.D. Orofacial pain and headache: a review and
look at the commonalities. Current pain and headache reports,
Philadelphia, v.18, no.3, p.1-6, Mar. 2014.
BENSON, S. et al. Obesity, depression, and chronic low-grade
inflammation in women with polycystic ovary syndrome. Brain,
behavior, and immunity, San Diego, v. 22, no. 2, p. 177-184, Feb.
CHALKOO, A.H. et al. Possible role of estrogen in
temporomandibular disorders in female subjects: A research
study. Journal of Indian Academy of Oral Medicine and
Radiology, v. 26, no. 1, p. 30. 2014.
COLLINS, M.; RALEIGH, S. Genetic risk factors for
musculoskeletal soft tissue injuries. Medicine and Sport Science,
v. 54, p.136-149, Feb. 2009.
CORREIA, L.M.F. et al. Importance of evaluating the
presence of temporomandibular disorders in chronic pain
patients. Revista Dor, São Paulo, v. 15, n. 1, p. 6-8. 2014.
DWORKIN, S.F.; LERESCHE, L. Research diagnostic criteria
for temporomandibular disorders: review, criteria, examinations
and specifications, critique. Journal of craniomandibular
disorders, Lombar, v.6, p.301-355. 1992.
FAUSER, B.C. et al. Consensus on women’s health aspects of
polycystic ovary syndrome (PCOS): The Amsterdam ESHRE/
ASRM-Sponsored 3rd PCOS Consensus Workshop Group.
Fertility and sterility, New York, v.97, no. 1, p.28-38, Jan. 2012.
HASSAN, S.; MUERE, A.; EINSTEIN, G. Ovarian hormones
and chronic pain: A comprehensive review. Pain, Amsterdam,
v.155, no.12, p. 2448-2460, Dec. 2014.
HOLLINRAKE, E. et al. Increased risk of depressive disorders
in women with polycystic ovary syndrome. Fertility and
sterility, New York, v. 87, no. 6, p. 1369-1376, Jun. 2007.
JUNIOR, G. et al. Adrenal androgen participation in the
polycystic ovary syndrome. Revista Brasileira de Ginecologia e
Obstetrícia, Rio de Janeiro, v.32, n.11, p.541-548, Nov. 2010.
KESSENBROCK, K.; CHIH-YANG, W.; WERB, Z. Matrix
metalloproteinases in stem cell regulation and cancer. Matrix
Biology, Stuttgart, May-Jul. 2015.
KRAMER, P.R.; BELLINGER, L.L. Modulation of
temporomandibular joint nociception and inflammation in
male rats after administering a physiological concentration of
β –oestradiol. European Journal of Pain, London, v.17, no.2,
p.174-184. 2012.
LEGRO, R.S. et al. Diagnosis and treatment of polycystic ovary
syndrome: an endocrine society clinical practice guideline. The
Journal of Clinical Endocrinology & Metabolism, v. 98, no. 12,
p. 4565-4592, Dec. 2013.
LEONARDI, R.; CALTABIANO, R.; LORETO,
C. Collagenase-3 (MMP-13) is expressed in periapical lesions: an
immunohistochemical study. International endodontic journal,
Oxford, v.38, no.5, p.297-301, May. 2005.
LIANG, M. et al. Regulation of hypoxia-induced cell death in
human tenocytes. Advances in operative orthopaedics, ST Louis,
v. 2012. 2012.
LOPEZ, C. et al. A pilot study of cognitive behavioral stress
management effects on stress, quality of life, and symptoms
in persons with chronic fatigue syndrome. Journal of
psychosomatic research, Oxford, v. 70, no. 4, p. 328-334, Apr.
LU, T. et al. Evidence that estrogen receptor beta enhances
MMP-13 promoter activity in HIG-82 cells and that this
enhancement can be influenced by ligands and involves specific
promoter sites. Biochemistry and cell biology, Ottawa, v.85, no.3,
p.326–336, Jun. 2007.
MCCRACKEN, L.M. et al. Pain-related anxiety predicts
non-specific physical complaints in persons with chronic
pain. Behaviour research and therapy, Oxford, v. 36, no. 6, p.
-630, Jun. 1998.
NANDI, A. et al. Polycystic ovary syndrome. Endocrinology
and metabolism clinics of North America, Philadelphia, v. 43,
no. 1, p. 123-147. 2014.
OLIVEIRA, J.A. et al. Female hormones fluctuation and
chewing movement of patients with disc displacement. Revista
Odonto Ciência, Porto Alegre, v. 27, n. 1, p. 20-25. 2012.
OZANNE, S.E. et al. Fetal growth and adult diseases. Seminars
in perinatology, New York, v.28, no.1, p.81-87. 2004.
PAPKA, R.E. et al. Localization of estrogen receptor protein
and estrogen receptor messenger RNA in peripheral autonomic
and sensory neurons. Neuroscience, Oxford, v.79, no.4,
p.1153–1163, Aug. 1997.
PEREIRA JÚNIOR, F.J. et al. Critérios de diagnóstico para
pesquisa das disfunções temporomandibulares (RDC/ TMD).
Tradução oficial para a língua portuguesa. Jornal Brasileiro de
Clínica Odontológica Integrada, Curitiba, v.8, n.47, p.384-395.
PROSKE, U. Muscle tenderness from exercise: mechanisms?.
The Journal of physiology, v.564, no.1, p.1-1. 2005.
RASGON, N. L. et al. Depression in women with polycystic
ovary syndrome: clinical and biochemical correlates. Journal of
affective disorders, Amsterdam, v. 74, no. 3, p. 299-304, May.
REPACI, A. et al. The role of low-grade inflammation in the
polycystic ovary syndrome. Molecular and cellular endocrinology,
Limerick, v. 335, no. 1, p. 30-41. 2011.
SHIMONOVITZ, S. et al. Expression of gelatinase B by
trophoblast cells: downregulation by progesterone. American
journal of obstetrics and gynecology, St. Louis, v.178, no.3,
p.457–461, Mar. 1998.
SOYDAN, S.S. et al. Is the incidence of temporomandibular
disorder increased in polycystic ovary syndrome?. British Journal
of Oral and Maxillofacial Surgery, Edinburgh, v. 52, no. 9, p.
-826, Nov. 2014.
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus
workshop group. Revised 2003 consensus on diagnostic criteria
and longterm health risks related to polycystic ovary syndrome
(PCOS). Human Reproduction, Oxford, v.19, no.1, p. 41-47.
WANG, J. et al. The possible role of estrogen in the incidence of
temporomandibular disorders. Medical hypotheses, Edinburgh, v.
, no. 4, p.564–567, Oct. 2008.
WEBER, B. et al. Testosterone, androstenedione and
dihydrotestosterone concentrations are elevated in female
patients with major depression. Psychoneuroendocrinology,
Oxford, v.25, no.8, p. 765-771, Nov. 2000.
WELT, C.K.; CARMINA, E. Lifecycle of polycystic ovary
syndrome (PCOS): from in utero to menopause. The Journal of
Clinical Endocrinology & Metabolism, v. 98, no. 12, p. 4629-
, Dec. 2013.
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