Association Between Parental Cocaine Use and Sudden Infant Death Syndrome: A Systematic Review

Autores/as

  • Sofia Holetz de Toledo Lourenço Faculdade de Medicina, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brasil. https://orcid.org/0009-0006-0316-5603
  • João Vítor Micherif Gudziki Tôrres Faculdade de Medicina, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brasil. https://orcid.org/0009-0005-9458-5816
  • Patrícia Cristina Gomes Pinto Departamento Materno Infantil, Faculdade de Medicina, Universidade Federal de Juiz de Fora, Brasil. https://orcid.org/0000-0002-4399-5787
  • Sabrine Teixeira Ferraz Grunewald Departamento Materno Infantil, Faculdade de Medicina, Universidade Federal de Juiz de Fora, Brasil. https://orcid.org/0000-0003-1288-1338

Palabras clave:

Sudden Infant Death, Cocaine, Cocaine-Related Disorders, Systematic Review

Resumen

Introduction: Sudden infant death syndrome (SIDS) is defined as the unexpected death of an infant under one year of age with no clear cause, typically occurring during sleep, and associated with various environmental risk factors. International recommendations for SIDS prevention include avoiding drug use, but the specific role of cocaine in increasing the risk of the syndrome is not well established. This is a systematic review of the literature on the association between parental cocaine use and the occurrence of SIDS. Objective: To conduct a systematic review of the literature on the association between parental cocaine use and the occurrence of SIDS. Material and Methods: The databases searched included PubMed/MEDLINE, Embase, Scopus, Web of Science, and LILACS, from their inception to December 2024. Study selection was conducted independently by two researchers, and disagreements were resolved by a third author. This review was registered in PROSPERO (CRD42024591448). Results: Eleven studies were included, all conducted in developed countries. A statistical analysis specifically correlating SIDS with cocaine use was available in seven studies, and in four of them, the results suggested an association between exposure and outcome. However, there were limitations related to the lack of data on the frequency, route, and intensity of drug use, with variation among studies in how this exposure was assessed. Conclusion: The studies analyzed in this systematic review suggest a possible association between cocaine use and the risk of SIDS. However, further research is needed to explore mechanisms related to maternal and paternal drug use during pregnancy and the postpartum period in order to establish a more accurate correlation with SIDS. 

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Citas

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Publicado

2026-03-17

Cómo citar

1.
Lourenço SH de T, Tôrres JVMG, Pinto PCG, Grunewald STF. Association Between Parental Cocaine Use and Sudden Infant Death Syndrome: A Systematic Review. HU Rev [Internet]. 17 de marzo de 2026 [citado 29 de marzo de 2026];51:1-9. Disponible en: https://periodicos.ufjf.br/index.php/hurevista/article/view/49308

Número

Vol. 51 (2025)

Sección

Artigos de Revisão Sistemática

Licencia

Derechos de autor 2026 Sofia Holetz de Toledo Lourenço, João Vítor Micherif Gudziki Tôrres, Patrícia Cristina Gomes Pinto, Sabrine Teixeira Ferraz Grunewald

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

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