Immunopathology of the murine experimental autoimmune encephalomyelitis mediated by T lymphocytes

Authors

  • Adriana Karla Gávio Silva Universidade Federal de Juiz de Fora
  • Márcio Luiz de Paula Universidade Federal de Juiz de Fora
  • Ana Paula Ferreira Universidade Federal de Juiz de Fora

Keywords:

Esclerose Múltipla. Encefalomielite Auto-imune Experimental. linfócitos T

Abstract

Multiple Sclerosis is a chronic, inflammatory and demyelinating disease of the Central Nervous System. Although its etiology is still unclear, it is supposed a CD4+ T Helper-1-mediated autoimmune disease. Experimental Autoimmune Encephalomyelitis (EAE) is an animal model to study Multiple Sclerosis. The characteristics of this model are inflammation and demyelination similar to Multiple Sclerosis. EAE allows to assess parameters such as CD4+ and CD8+ T lymphocytes, regulatory T lymphocytes, costimulatory molecules, chemokines and so on. The aim of this study was to make a bibliographic revision of the murine EAE immunopathology mediated by T cells.

Keywords: Multiple Sclerosis. Experimental Autoimmune Encephalomyelitis.  T lymphocytes.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

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Author Biographies

Adriana Karla Gávio Silva, Universidade Federal de Juiz de Fora

Fisioterapeuta especialista em Fisioterapia Dermato-Funcional e em Parasitologia, Microbiologia e Imunologia. Mestranda em Imunologia pela Universidade Federal de Juiz de Fora

Márcio Luiz de Paula, Universidade Federal de Juiz de Fora

Farmacêutico e Bioquímico. Mestre em Ciências da Saúde - Universidade Federal de Juiz de Fora

Ana Paula Ferreira, Universidade Federal de Juiz de Fora

Professora Adjunta de Imunologia - Universidade Federal de Juiz de Fora

Published

2009-03-06

How to Cite

1.
Gávio Silva AK, de Paula ML, Ferreira AP. Immunopathology of the murine experimental autoimmune encephalomyelitis mediated by T lymphocytes. HU Rev [Internet]. 2009Mar.6 [cited 2024Nov.21];34(3). Available from: https://periodicos.ufjf.br/index.php/hurevista/article/view/236

Issue

Section

Artigos de Revisão da Literatura