Immunopathology of the murine experimental autoimmune encephalomyelitis mediated by T lymphocytes
Keywords:
Esclerose Múltipla. Encefalomielite Auto-imune Experimental. linfócitos TAbstract
Multiple Sclerosis is a chronic, inflammatory and demyelinating disease of the Central Nervous System. Although its etiology is still unclear, it is supposed a CD4+ T Helper-1-mediated autoimmune disease. Experimental Autoimmune Encephalomyelitis (EAE) is an animal model to study Multiple Sclerosis. The characteristics of this model are inflammation and demyelination similar to Multiple Sclerosis. EAE allows to assess parameters such as CD4+ and CD8+ T lymphocytes, regulatory T lymphocytes, costimulatory molecules, chemokines and so on. The aim of this study was to make a bibliographic revision of the murine EAE immunopathology mediated by T cells.
Keywords: Multiple Sclerosis. Experimental Autoimmune Encephalomyelitis. T lymphocytes.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
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