Multiple oral manifestations in cutaneous lupus erythematosus

Authors

  • Sara Luisa Lima Cusini Universidade Federal de Juiz de Fora Campus Governador Valadares, Minas Gerais https://orcid.org/0000-0001-9154-7922
  • Ranam Moreira Reis Universidade Federal de Juiz de Fora Campus Governador Valadares, Minas Gerais https://orcid.org/0000-0001-8001-5541
  • Fernanda Mombrini Pigatti Departamento de Odontologia, Universidade Federal de Juiz de Fora Campus Governador Valadares, Minas Gerais https://orcid.org/0000-0001-8495-8571
  • Cleverton Correa Rabelo Departamento de Odontologia, Universidade Federal de Juiz de Fora Campus Governador Valadares, Minas Gerais https://orcid.org/0000-0001-9286-0988
  • Francielle Silvestre Verner Departamento de Odontologia, Universidade Federal de Juiz de Fora Campus Governador Valadares, Minas Gerais https://orcid.org/0000-0001-5770-316X
  • Sibele Nascimento de Aquino Departamento de Odontologia, Universidade Federal de Juiz de Fora Campus Governador Valadares, Minas Gerais https://orcid.org/0000-0003-3843-3517

DOI:

https://doi.org/10.34019/1982-8047.2021.v47.32896

Keywords:

Cutaneous Lupus Erythematosus, Mouth Mucosa, Lichenoid Eruptions

Abstract

Introduction: Chronic cutaneous lupus erythematosus (SCCL) is an autoimmune inflammatory disease, with characteristic skin lesions. Intraoral manifestations are described and may have similar aspects to other lesions of autoimmune origin, highlighting the need for assessment and diagnosis of lesions in the oral mucosa by the dentist. Objective: To present a case of cutaneous lupus erythematosus with multiple oral manifestations, without simultaneous skin lesions, focusing on clinical, histopathological and serological exams to investigate systemic involvement. Case Report: A 54-year-old woman with a history of lupus attended the clinic with a lichenoid-like lesion on the lower lip and an extensive, erythematous area with reticular lines and asymptomatic was observed on the hard palate. Desquamative gingivitis was observed in the maxilla and mandible. There were lichenoid and pigmented areas in the jugal mucosa. Incisional biopsy was performed on the hard palate and histopathological analysis revealed a fragment of the oral mucosa showing hyperkeratosis and focal degeneration of the basal layer. Additional tests were requested which ruled out systemic involvement. Conclusion: This case highlights the diversity of oral manifestations in a patient with lupus and the importance of examining the oral mucosa, even in the absence of skin lesions, which are more common. The participation of the dental surgeon in the multidisciplinary team of patients undergoing treatment for lupus erythematosus is essential.

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References

Blake SC, Daniel BS. Cutaneous lupus erythematosus: A review of the literature. Int J Womens Dermatol. 2019 Jul 31; 5(5):320-329.

Petty AJ, Floyd L, Henderson C, Nicholas MW. Cutaneous Lupus Erythematosus: Progress and Challenges. Curr Allergy Asthma Rep. 2020; 20(5):12.

Yadav S, Patra S, Singh A. Unilateral discoid lupus erythematosus over the face: An unusual presentation. Indian Dermatol Online J. 2018 Jul-Ago; 9(4):268-269. doi:10.4103/idoj.IDOJ_173_17

Carrozzo M, Porter S, Mercadante V, Fedele, S. Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management, strategies. Periodontol 2000. 2019 Jun;80(1):105-125. doi: 10.1111/prd.12260

Saccucci M, Di Carlo G, Bossù M, Giovarruscio F, Salucci A, Polimeni A. Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management. J Immunol Res. 2018 May:6061825. doi: 10.1155/2018/6061825

Chang J; Werth VP. Therapeutic options for cutaneous lupus erythematosus: recent advances and future prospects. Expert Rev Clin Immunol. 2016 Oct; 12(10): 1109–1121. doi:10.1080/1744666X.2016.1188006

Izmirly P, Buyon J, Belmont HM, Sahl S, Wan I, Salmon J, et al. Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program. Lupus Sci Med. 2019 Oct; 6(1):e000344corr1. doi:10.1136/lupus-2019-000344

Jarrett P, Werth VP. A review of cutaneous lupus erythematosus: improving outcomes with a multidisciplinary approach. J Multidiscip Healthc. 2019 May;31(12):419–428. doi: 10.2147/JMDH.S179623

Elman SA, Joyce C, Costenbader KH, Merola JF. Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. Clin Exp Dermatol. 2020 Jan;45(1):89-91. doi: 10.1111/ced.14014

Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012; 64(8):2677-86.

Szczęch J, Rutka M, Samotij D, Zalewska A, Reich A. Clinical characteristics of cutaneous lupus erythematosus. Adv Dermatol Allergol. 2016 Feb; 33(1):13–17. DOI: 10.5114/pdia.2014.44031

Adwan, M. Clinical and Serologic Characteristics of Systemic Lupus Erythematosus in the Arab World: A Pooled Analysis of 3,273 Patients. Arch Rheumatol. 2018 Mar;33(4):455-463. doi: 10.5606/ArchRheumatol.2018.6832

Del Barrio-Díaz P, Reyes-Vivanco C, Cifuentes-Mutinelli M, Manríquez J, Vera-Kellet C. Association between oral lesions and disease activity in lupus erythematosus. J Eur Acad Dermatol Venereol. 2020 Feb; 34(2):349-356. doi: 10.1111/jdv.15980

Mao QX, Zhang WL, Wang Q, Xiao XM, Chen H, Shao XB, et al. Linear cutaneous lupus erythematosus/discoid lupus erythematosus in an adult. Postepy Dermatol Alergol. 2017 Apr; 34(2):177-179. DOI: https://doi.org/10.5114/ada.2017.67086

Manikkath S, Venkatta RB, Nair SP, Kumar GN. Verrucous disseminated discoid lupus erythematosus with plantar and oral lesions in the absence of systemic lupus erthyematosus. Indian Dermatol Online J. 2018 Mar-Apr;9(2):129-131. doi: 10.4103/idoj.IDOJ_125_17

Arvanitidou IE, Nikitakis NG, Georgaki M, Papadogeorgakis N, Tzioufas A, Sklavounou A. Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Feb; 125(2):e22-e30. doi: 10.1016/j.oooo.2017.08.012

Gamble M, Tocci E, Venna S, Reserva J, Radfar A, Dugan EM. Poorly differentiated squamous cell carcinoma arising within a lesion of discoid lupus erythematosus in an African-American woman. JAAD Case Rep. 2015 May; 1(3):138-140. doi:10.1016/j.jdcr.2015.03.009

Singh AG, Crowson CS, Singh S, Davis MDP, Maradit-Kremers H, Matteson EL, et al. Cancer risk in cutaneous lupus erythematosus: a population-based cohort study. Rheumatology (Oxford). 2016 Nov; 55(11):2009-2013. doi:10.1093/rheumatology/kew291

Rodsaward P, Prueksrisakul T, Deekajorndech T, Edwards SW, Beresford MW, Chiewchengchol D. Oral Ulcers in Juvenile-Onset Systemic Lupus Erythematosus: A Review of the Literature. Am J Clin Dermatol. 2017 Dec;18(6):755-762.

Shi H, Gudjonsson JE, Kahlenberg JM. Treatment of cutaneous lupus erythematosus: current approaches and future strategies. Curr Opin Rheumatol. 2020; 32(3):208-214.

Published

2021-06-14

How to Cite

1.
Luisa Lima Cusini S, Moreira Reis R, Mombrini Pigatti F, Correa Rabelo C, Silvestre Verner F, Nascimento de Aquino S. Multiple oral manifestations in cutaneous lupus erythematosus. HU Rev [Internet]. 2021Jun.14 [cited 2024Nov.21];47:1-8. Available from: https://periodicos.ufjf.br/index.php/hurevista/article/view/32896

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