Microbiota bucal versus mucosite oral durante o tratamento para o câncer: uma revisão

  • Izabella Henrichs Ribeiro
  • Júlia Ferigatto
  • Dionéia Evangelista Cesar
  • Rodrigo Luiz Fabri
  • Ana Carolina Morais Apolônio Instituto de ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia
Palavras-chave: Estomatite, Microbiota bucal, Neoplasias de Cabeça e Pescoço

Resumo

Introdução: A microbiota bucal tem sido associada à mucosite oral que ocorre durante a terapia para o câncer apesar de não haver consenso.  Objectivo: Este estudo objetivou estabelecer por meio de uma revisão da literatura a associação entre a microbiota bucal e a mucosite oral durante a Terapia para o Câncer de Cabeça e Pescoço (TCCP). Material e métodos: Foi realizada uma busca na base de dados PubMed no período de 2008-2018 utilizando-se as palavras chave “oral mucositis” e “oral microbiota” nos subtítulos “etiology” e “microbiology” do descritor “Head and Neck Neoplasms” da base Medical Subject Heading (MeSH). A questão norteadora do estudo foi: “Ocorre uma disbiose durante a terapia para o câncer de cabeça e pescoço que esteja associada à mucosite oral?”. Resultados: 22 artigos foram selecionados em duas etapas de extração dos dados: artigos que avaliaram a microbiota bucal durante TCCP (n=13), e artigos que também focaram na mucosite oral (n=9). Conclusão: A evidência apresentada na literatura sugere associação de uma disbiose da microbiota bucal com a progressão e agravamento da mucosite oral induzida pela radiação. Entretanto, novos estudos padronizados são necessários para se definir o core microbiano para a doença.

Referências

Zhu XX, Yang XJ, Chao YL, Zheng HM, Sheng HF, Liu HY et al. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma. EBioMedicine. 2017; 18:23-31.

Hou J, Zheng H, Li P, Liu H, Zhou H, Yang X. Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy. Radiother Oncol. 2018; 129(1):44-51.

Vidal-Casariego A, Fernández-Natal I, Calleja-Fernández A, Parras-Padilla T, Cano-Rodríguez I, Prieto-Alonso B et al. Nutritional, microbiological, and therapeutic factors related to mucositis in head and neck cancer patients: a cohort study. Nutr Hosp. 2015; 32:1208-13.

Stringer AM, Logan RM. The role of oral flora in the development of chemotherapy-induced oral mucositis. J Oral Pathol Med. 2015; 44(2):81-7.

Gaetti-Jardim Jr. E, Jardim ECG, Schweitzer CM, Silva JCF, Oliveira MM, Masocatto DC et al. Supragingival and subgingivalmicrobiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment. Arch Oral Biol. 2018; 90:45-52. doi: 10.1016/j.archoralbio.2018.01.003.

Hu YJ, Shao ZY, Wang Q, Jiang YT, Ma R, Tang ZS et al. Exploring the dynamic core microbiome of plaque microbiota during headand-neck radiotherapy using pyrosequencing. PLoS One. 2013; 8(2):e56343.

Vanhoecke B, Ryck T, Stringer A, Van De Wiele T, Keefe D. Microbiota and their role in the pathogenesis of oral mucositis. Oral Dis. 2015; 21(1):17-30.

Maria OM, Eliopoulos N, Muanza T. Radiation-induced oral mucositis. Front Oncol. 2017; 7:89.

MEDLINE [Internet]. Wikipédia: a enciclopédia livre. 2018. [citado em 2019 Feb 11]. Disponível em: https://pt.wikipedia.org/wiki/MEDLINE.

Ye Y, Carlsson G, Agholme MB, Wilson JA, Roos A, Henriques-Normark B et al. Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: a prospective study. Clin Microbiol Infect. 2013; 19(12):e559-67.

Almståhl A, Finizia C, Carlen A, Fagerberg-Mohlin B, Alstad T. Mucosal microflora in head and neck cancer patients. Int J Dent Hyg. 2018; 16(4):459-66.

Ognjenović M, Milatić K, Parat K, Kovacić I, Buselić Ma, Bozić J. Mucositis grades and yeast species. Coll Antropol. 2013; 37(2):443-7.

Vozza I, Caldarazzo V, Ottolenghi L. Changes in microflora in dental plaque from cancer patients undergoing chemotherapy and the relationship of these changes with mucositis: a pilot study. Med Oral Patol Oral Cir Bucal. 2015; 20(3):e259-66.

Singh GK, Capoor MR, Nair D, Bhowmik KT. Spectrum of fungal infection in head and neck cancer patients on chemoradiotherapy. J Egypt Natl Canc Inst. 2017; 29(1):33-7.

Kawashita Y, Funahara M, Yoshimatsu M, Nakao N, Soutome S, Saito T et al. A retrospective study of factors associated with the development of oral candidiasis in patients receiving radiotherapy for head and neck cancer: is topical steroid therapy a risk factor for oral candidiasis? Medicine (Baltimore). 2018; 97(44):13073.

Marsh P, Martin MV, Lewis MAO. Oral microbiology. London: Elsevier; 2009.

The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012; 468(7402):207-14.

Bulacio L, Paz M, Ramadán S, Ramos L, Pairoba C, Sortino M et al. Oral infections caused by yeasts in patients with head and neck cancer undergoing radiotherapy: identification of the yeasts and evaluation of their antifungal susceptibility. J Mycol Med. 2012; 22(4):348-53.

Tomkovich S, Jobin C. Microbiota and host immune responses: a love-hate relationship. Immunology. 2016; 147(1):1-10.

Schmidt BL, Kuczynski J, Bhattacharya A, Huey B, Corby PM, Queiroz EL et al. Changes in abundance of oral microbiota associated with oral cancer. PLoS One. 2014; 9(6):e98741.

Mok SF, Karuthan C, Cheah Yk, Ngeow WC, Rosnah Z, Yap SF et al. The oral microbiome community variations associated with normal, potentially malignant disorders and malignant lesions of the oral cavity. Malays J Pathol. 2017; 39(1):1-15.

Yang CY, Yeh YM, Yu HY, Chin CY, Hsu CW, Liu H et al. Oral microbiota community dynamics associated with oral squamous cell carcinoma. Front Microbiol. 2018; 9:862.

Schuurhuis JM, Stokman MA, Witjes MJ, Langendijk JA, van Winkelhoff AJ, Vissink A et al. Head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens. Oral Oncol. 2016; 58:32-40.

Xu Y, Teng F, Huang S, Lin Z, Yuan X, Zeng X et al. Changes of saliva microbiota innasopharyngeal carcinoma patients under chemoradiation therapy. Arch Oral Biol. 2014; 59(2):176-86.

Chen X, Winckler B, Lu M, Zhang Y, Jin L, Ye W. Poor oral health is associated with an increased risk of esophageal squamous cell carcinoma: a population-based case-control study in China. Int J Cancer. 2015; 140(3):626-35.

Zhao H, Chu M, Huang Z, Yang X,Ran S, Hu B et al. Variations in oral microbiota associated with oral cancer. Sci Rep. 2017; 7(1):11773.

Gao L, Hu Y, Wang Y, Jiang W, He Z, Zhu C et al. Exploring the variation of oral microbiota insupragingival plaque during and after head-and-neck radiotherapy using pyrosequencing. Arch Oral Biol. 2015; 60(9):1222-30.

Raj S, Sharma D, Mate P, Capoor MR, Bhowmik KT. A study of changes in the oral fungal flora of patients on radiotherapy for head and neck malignancies and their correlation with funguria and fungemia. Indian J Cancer. 2017; 54(1):39-42.

Goodman JL, Winston DJ, Greenfield RA, Chandrasekar PH, Fox B, Kaizer H et al. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med. 1992; 326(13):845-51.

Buglione M, Cavagnini R, Rosario F, Maddalo M, Vassali L, Grisanti S et al. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: xerostomia and trismus (part 2): literature review and consensus statement. Crit Rev Oncol Hematol. 2016; 102:47-54.

Pushalkar S, Ji X, Li Y, Estilo C, Yegnanarayana R, Singh B et al. Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma. BMC Microbiol. 2012; 12:144. doi: 10.1186/1471-2180-12-144.

Yang SF, Huang HD, Fan WL, Jong YJ, Chen MK, Huang CN et al. Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer. Oral Oncol. 2018; 77:1-8. doi: 10.1016/j.oraloncology.2017.12.005.

Publicado
2020-04-08
Como Citar
1.
Ribeiro IH, Ferigatto J, Cesar DE, Fabri RL, Apolônio ACM. Microbiota bucal versus mucosite oral durante o tratamento para o câncer: uma revisão. hu rev [Internet]. 8º de abril de 2020 [citado 4º de junho de 2020];460:1-. Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/28995
Seção
Artigos de Revisão da Literatura

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