Lasertherapy for salivary glands and taste disorders in patients undergoing radiotherapy: literature review

Authors

  • Genielle Luiza Pereira Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares
  • Manuela Lima Barros de Oliveira Programa de Pós-Graduação Ciências Aplicadas à Saúde. Universidade Federal de Juiz de Fora – Campus Governador Valadares
  • Fernanda Mombrini Pigatti Departamento de Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares
  • Francielle Silvestre Verner Programa de Pós-Graduação Ciências Aplicadas à Saúde e Departamento de Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares http://orcid.org/0000-0001-5770-316X

DOI:

https://doi.org/10.34019/1982-8047.2020.v46.29171

Keywords:

Ageusia, Head and Neck Cancer, Radiotherapy, Low Level Laser Therapy, Xerostomy

Abstract

Introduction: Radiotherapy is one of the most widely used treatment modality in patients with head and neck cancer, but adverse effects are common in most patients. Objective: To conduct an updated review of the scientific literature to verify the impact of radiotherapy on the salivary glands and taste buds of patients undergoing treatment for head and neck cancer, and to evaluate the efficacy of treatment with low-power laser therapy in an attempt to reduce signs and symptoms related to changes in such structures. Material and Methods: This was a bibliographic research with information collection in the PubMed database. Articles were selected that treated patients diagnosed with head and neck cancer who were or would have been treated with radiotherapy, published between 2000 and 2019. Results: A great impact on the quality of life of radiotherapy patients was observed, since treatment causes damage to taste buds and salivary glands, and may be reversible or not. The degree of commitment and the time that these organs develop their basic functions were not well clarified due to the lack of standardization in the choices of the methods for research. Conclusion: Low intensity laser has been shown to be effective in controlling hyposalivation and dysgeusia in most studies, but more research is needed to prove its benefits, so that in the future it can be an ally in the prevention and control of consequences from radiotherapy.

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Author Biographies

Genielle Luiza Pereira, Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares

Estudante de Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares.

Manuela Lima Barros de Oliveira, Programa de Pós-Graduação Ciências Aplicadas à Saúde. Universidade Federal de Juiz de Fora – Campus Governador Valadares

Mestranda, Programa de Pós-Graduação Ciências Aplicadas à Saúde. Universidade Federal de Juiz de Fora – Campus Governador Valadares.

Fernanda Mombrini Pigatti, Departamento de Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares

PhD, Professora, Departamento de Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares.

Francielle Silvestre Verner, Programa de Pós-Graduação Ciências Aplicadas à Saúde e Departamento de Odontologia, Instituto de Ciências da Vida, Universidade Federal de Juiz de Fora – Campus Governador Valadares

Doutora em Radiologia Odontológica - UNICAMP

References

Instituto Nacional do Câncer (INCA). c2018 [acessado em 04 de outubro de 2019]. Disponível em: http://www1.inca.gov.br/estimativa/2018/casos-taxas-brasil.asp.

González-Arriagada WA, Ramos LMA, Andrade MAC, Lopes MA. Efficacy of low-level laser therapy as an auxiliary tool for management of acute side effects of head and neck radiotherapy. J Cosmet Laser Ther. 2018; 20(2):117-12.

Palma LF, Gonnelli FAZ, Marcucci M, Dias RS, Giordani AJ, Segreto RA et al. Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci. 2017; 32(4):827-32.

Saleh J, Figueiredo MA, Cherubini K, Braga-Filho A, Salum FG. Effect of low-level laser therapy on radiotherapy-induced hyposalivation and xerostomia: a pilot study. Photomed Laser Surg. 2014; 32(10):546-52.

Almstahl A, Alstad T, Fagerberg-Mohlin B, Carlén A, Finiza C. Explorative study on quality of life in relation to salivary secretion rate in patients with head and neck cancer treated with radiotherapy. 2016; 38(5):782-91.

Barbosa da Silva JL, Doty RL, Miyazaki JVMK, Borges R, Pinna FR, Voegels RL et al. Gustatory disturbances occur in patients with head and neck cancer who undergo radiotherapy not directed to the oral cavity. Oral Oncol. 2019; 95:115-9.

Baharvand M, ShoalehSaadi N, Barakian R, Moghaddam EJ. Taste alteration and impact on quality of life after head and neck radiotherapy. J Oral Pathol Med. 2013; 42(1):106-12.

Lončar B, Stipetić MM, Baričević M, Risović D. The effect of low-level laser therapy on salivary glands in patients with xerostomia. Photomed Laser Surg. 2011; 29(3):171-5.

Braam PM, Roesink JM, Raaijmakers CP, Busschers WB, Terhaard CH. Quality of life and salivary output in patients with head-and-neck cancer five years afterradiotherapy. Radiat Oncol. 2007; 5:2-3.

Jellema AP, Slotman BJ, Doornaert P, Leemans CR, Langendijk JA. Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 2007; 69(3):751-60.

Mercadante V, Hamad AA, Lodi G, Porter S, Fedele S. Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: a systematic review and meta-analysis. Oral Oncol. 2017; 66:64-74.

Shi HB, Masuda M, Umezaki T, Kuratomi Y, Kumamoto Y, Yamamoto T et al. Irradiation impairment of umami taste in patients with head and neck cancer. Auris Nasus Larynx. 2004; 31(4):401-6.

Ruo Redda MG, Allis S. Radiotherapy-induced taste impairment. Cancer Treat Rev. 2006; 32(7):541-7.

Epstein JB, Andrei Barasch A. Taste disorders in cancer patients: Pathogenesis, and approach to assessment and management. Oral Oncol. 2010; 46(2):77-81.

McLaughlin L. Taste dysfunction in head and neck cancer survivors. Oncol Nurs Forum. 2013; 40(1):E4-13.

Irune E, Dwivedi RC, Nutting CM, Harrington KJ. Treatment-related dysgeusia in head and neck cancer patients. Cancer Treat Rev. 2014; 40(9):1106-17.

Deshpande TS, Blanchard P, Wang L, Foote RL, Zhang X, Frank SJ. Radiation-related alterations of taste function in patients with head and neck cancer: a systematic review. Curr Treat Options in Oncol. 2018; 19:72.

Chen WC, Tsai MS, Tsai YT, Lai CH, Lee CP, Chen MF. Long-term taste impairment after intensity-modulated radiotherapy to treat head-and-neck cancer: correlations with glossectomy and the mean radiation dose to the oral cavity. Chem Senses. 2019; 44(5):319-26.

Simões A, de Campos L, de Souza DN, de Matos JA, Freitas PM, Nicolau J. Laser phototherapy as topical prophylaxis against radiation-induced xerostomia. Photomed Laser Surg. 2010; 28(3):357-63.

Oton-Leite AF, Elias LS, Morais MO, Pinezi JC, Leles CR, Silva MA et al. Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy. Spec Care Dentist. 2013; 33(6):294-300.

Gonnelli FA, Palma LF, Giordani AJ, Deboni AL, Dias RS, Segreto RA et al. Low-level laser for mitigation of low salivary flow rate in head and neck cancer patients undergoing radiochemotherapy: a prospective longitudinal study. Photomed Laser Surg. 2016; 34(8):326-30.

Brzak BL, Cigic L, Baricevic´ M, Sabol I, Mravak-Stipetic´ M, Risovic´ D. Different protocols of photobiomodulation therapy of hyposalivation. Photomed Laser Surg. 2018; 36(2):78-82.

Migliario M, Sabbatini M, Mortellaro C, Renò F. Near infrared low-level laser therapy and cell proliferation:the emerging role of redox sensitive signal transduction pathways. J Biophotonics. 2018; 11(11).

Published

2020-07-28

How to Cite

1.
Pereira GL, Lima Barros de Oliveira M, Mombrini Pigatti F, Verner FS. Lasertherapy for salivary glands and taste disorders in patients undergoing radiotherapy: literature review. HU Rev [Internet]. 2020Jul.28 [cited 2024Jul.17];46:1-8. Available from: https://periodicos.ufjf.br/index.php/hurevista/article/view/29171

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Section

Artigos de Revisão da Literatura

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