O papel do dolutegravir na terapia antiretroviral

Autores

  • Tamyres dos Santos Vieira Faculdade de Medicina, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora - Suprema, Juiz de Fora, MG
  • Isabela dos Santos Vieira Centro de Ensino Superior de Valença, CESVA/FAA – Valença, RJ
  • Matheus Bresser Faculdade de Medicina, Universidade Federal de Juiz de Fora –UFJF, Juiz de Fora, MG
  • Letícia Coutinho Lopes Moura Faculdade de Medicina, Universidade Federal de Juiz de Fora –UFJF, Juiz de Fora, MG
  • Marcos de Assis Moura Faculdade de Medicina, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora - Suprema, Juiz de Fora, MG Faculdade de Medicina, Universidade Federal de Juiz de Fora –UFJF, Juiz de Fora, MG

DOI:

https://doi.org/10.34019/1982-8047.2018.v44.13945

Palavras-chave:

HIV, Terapia Antirretroviral de Alta Atividade, Síndrome de Imunodeficiência Adquirida, Carga Viral, Dolutegravir

Resumo

Os inibidores da integrase são a mais nova classe de antirretroviral aprovada, que agem impedindo a incorporação do DNA do HIV no genoma do linfócito T CD4+ (LTCD4+) do hospedeiro, limitando a propagação do vírus. O Dolutegravir e o inibidor da integrase mais moderno e como os demais inibidores apresenta de alta performance, boa tolerância; alta barreira genética para mutações de resistência, além de apresentar eficácia em pacientes já submetidos a tratamento antirretroviral anterior. Neste contexto o presente estudo trata-se de um estudo de revisão bibliográfica realizada de janeiro a junho de 2018, de artigos científicos de artigos científicos que abordam aspectos exclusivos do dolutegravir na terapia antirretroviral em comparação com outros esquemas terapêuticos. Concluindo que o tratamento com dolutegravir apresenta como principais vantagens à rápida supressão virológica; boa tolerância e alta barreira genética para mutações de resistência.

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Publicado

2019-06-21

Como Citar

1.
Vieira T dos S, Vieira I dos S, Bresser M, Moura LCL, Moura M de A. O papel do dolutegravir na terapia antiretroviral. hu rev [Internet]. 21º de junho de 2019 [citado 5º de outubro de 2022];44(3):379-85. Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/13945

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