Biocompatibilidad en pulpotomía: mejor material y alternativas al uso de MTA - una revisión sistemática y metanálisis
DOI:
https://doi.org/10.34019/1982-8047.2023.v49.40598Palabras clave:
Agentes de Capeamento da Polpa Dentária e Pulpectomia, Materiais Biocompatíveis, PulpotomiaResumen
Introducción: La terapia pulpar vital es un tratamiento dirigido a mantener la vitalidad pulpar y la función dentaria. Para la pulpotomía, los materiales se eligen en función de algunas características fundamentales, como la biocompatibilidad y la bioactividad. Objetivo: El objetivo de esta investigación es identificar el mejor material para uso en pulpotomía considerando la propiedad de biocompatibilidad, a través de una revisión sistemática de la literatura y metanálisis. Materiales y Métodos: La pregunta orientadora fue: “¿Cuál es el mejor agente para pulpotomía considerando la propiedad de biocompatibilidad?”. Se realizó una búsqueda en las bases de datos electrónicas MEDLINE/PubMed, SciELO, LILACS y Web of Science desde su inicio hasta octubre de 2020, utilizando los siguientes descriptores reconocidos por Medical Subject Headings (MeSH): “pulpotomy”, “pulp therapy”, “biomaterials” , “materiales biocompatibles”, “agente de recubrimiento pulpar”, “materiales de recubrimiento pulpar”. La búsqueda se basó en el acrónimo PICOS, desarrollado de acuerdo con PRISMA y registrado en la base de datos PROSPERO (CRD42020191891). El riesgo de sesgo y el metanálisis se realizaron con herramientas Cochrane. Resultados: Como resultado, se recuperaron 358 estudios, 15 de ellos fueron admitidos al análisis cualitativo y seis al análisis cuantitativo. La investigación evaluó aspectos clínicos, radiográficos e histológicos, considerando diferentes periodos de seguimiento, muestras y metodologías. Se encontraron varios materiales y el MTA fue el más estudiado. Aunque los resultados cualitativos no fueron concluyentes en relación al mejor de ellos, fue posible establecer alternativas viables para el reemplazo de MTA. Conclusión: En conclusión, se pudo obtener, a través del metaanálisis, que el MTA es el material más favorable para su uso en pulpotomías en dientes temporales.
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Bhagat D, Sunder RK, Devendrappa SN, Vanka A, Choudaha N. A comparative evaluation of ProRoot mineral trioxide aggregate and Portland cement as a pulpotomy medicament. J Indian Soc Pedod Prev Dent. 2016; 34(2):172-6. doi: 10.4103/0970-4388.180448
Ashraf H, Rahmati A, Amini N. Vital pulp therapy with calcium-silicate cements: report of two cases. Iran Endod J. 2017; 12(1):112-5. doi: 10.22037/iej.2017.23
Sirohi K, Marwaha M, Gupta A, Bansal K, Srivastava A. Comparison of clinical and radiographic success rates of pulpotomy in primary molars using ferric sulfate and bioactive tricalcium silicate cement: an in vivo study. Int J Clin Pediatr Dent. 2017; 10(2):147-51. doi: 10.5005/jp-journals-10005-1425
Gonzalez-Lara A, Ruiz-Rodriguez MS, Pierdant-Perez M, Garrocho-Rangel JA, Pozos-Guillen AJ. Zinc oxide-eugenol pulpotomy in primary teeth: a 24-month follow-up. J Clin Pediatr Dent. 2016; 40(2):107-12. doi: 10.17796/1053-4628-40.2.107
Juneja P, Kulkarni S. Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars. Eur Arch Paediatr Dent. 2017; 18(4):271-8. doi: 10.1007/s40368-017-0299-3
Abuelniel GM, Duggal MS, Kabel N. A comparison of MTA and Biodentine as medicaments for pulpotomy in traumatized anterior immature permanent teeth: a randomized clinical trial. Dent Traumatol. 2020; 36(4):400-10. doi: 10.1111/edt.12553
Collado-González M, García-Bernal D, Oñate-Sánchez RE, Ortolani-Seltenerich PS, Álvares-Muro T, Lozano A et al. Cytotoxicity and bioactivity of various pulpotomy materials on stem cells from human exfoliated primary teeth. Int Endod J. 2017; 50 Suppl 2:e19-e30. doi: 10.1111/iej.12751
Bakhtiar H, Nekoofar MH, Aminishakib P, Abedi F, Moosavi FN, Esnaashari P et al. Human pulp responses to partial pulpotomy treatment with theracal as compared with Biodentine and ProRoot MTA: a clinical trial. J Endod. 2017; 43(11):1786-91. doi: 10.1016/j.joen.2017.06.025
Taha NA, Abdulkhader SZ. Full pulpotomy with Biodentine in symptomatic young permanent teeth with carious exposure. J Endod. 2018; 44(6):932-7. doi: 10.1016/j.joen.2018.03.003
Prabhakar AR, Mandroli PS, Bhat K. Pulpotomy with curcumin: histological comparison with mineral trioxide aggregate in rats. Indian J Dent Res. 2019; 30(1):31-6. doi: 10.4103/ijdr.IJDR_278_17
Silva LLCE, Cosme-Silva L, Sakai VT, Lopes CS, Silveira APP, Moretti Neto RF et al. Comparison between calcium hydroxide mixtures and mineral trioxide aggregate in primary teeth pulpotomy: a randomized controlled trial. J Appl Oral Sci. 2019; 27:e20180030. doi: 10.1590/1678-7757-2018-0030
Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RG. Efficacy of three different pulpotomy agents in primary molars: a randomized control trial. Int Endod J. 2017; 50(3):215-28. doi: 10.1111/iej.12619
Yildirim C, Basak F, Akgun OM, Polat GG, Altun C. Clinical and radiographic evaluation of the effectiveness of formocresol, mineral trioxide aggregate, portland cement, and enamel matrix derivative in primary teeth pulpotomies: a two year follow-up. J Clin Pediatr Dent. 2016; 40(1):14-20. doi: 10.17796/1053-4628-40.1.14
Caruso S, Dinoi T, Marzo G, Campanella V, Giuca MR, Gatto R et al. Clinical and radiographic evaluation of biodentine versus calcium hydroxide in primary teeth pulpotomies: a retrospective study. BMC Oral Health. 2018; 18(1):54. doi: 10.1186/s12903-018-0522-6
Gandolfi MG, Spagnuolo G, Siboni F, Procino A, Rivieccio V, Pelliccioni GA et al. Calcium silicate/calcium phosphate biphasic cements for vital pulp therapy: chemical-physical properties and human pulp cells response. Clin Oral Investig. 2015; 19(8):2075-89. doi: 10.1007/s00784-015-1443-2
Cuadros-Fernández C, Lorente Rodríguez AI, Sáez-Martínez S, García-Binimelis J, About I, Mercadé M. Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial. Clin Oral Investig. 2016; 20(7):1639-45. doi: 10.1007/s00784-015-1656-4
Awawdeh L, Al-Qudah A, Hamouri H, Chakra RJ. Outcomes of vital pulp therapy using mineral trioxide aggregate or biodentine: a prospective randomized clinical trial. J Endod. 2018; 44(11):1603-9. doi: 10.1016/j.joen.2018.08.004
Martens L, Rajasekharan S, Cauwels R. Pulp management after traumatic injuries with a tricalcium silicate-based cement (Biodentine™): a report of two cases, up to 48 months follow-up. Eur Arch Paediatr Dent. 2015; 16(6):491-6. doi:10.1007/s40368-015-0191-y
Marconyak LJ Jr, Kirkpatrick TC, Roberts HW, Roberts MD, Aparicio A, Himel VT, et al. A comparison of coronal tooth discoloration elicited by various endodontic reparative materials. J Endod. 2016; 42(3):470-3. Doi: 10.1016/j.joen.2015.10.013
Woodmansey KF, Kohout GD, Primus CM, Schneiderman E, Opperman LA. histologic assessment of quick-set and mineral trioxide aggregate pulpotomies in a canine model. J Endod. 2015; 41(10):1626-30. Doi: 10.1016/j.joen.2015.05.006
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:71. Doi: 10.1136/bmj.n71
Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366:4898. Doi: 10.1136/bmj.l4898
Bengtson AL, Bengtson NG, Bengtson CRG, Pinheiro SL, Guedes-Pinto, AC. Pulpotomy in human deciduous teeth and bone morphogenetic protein (rhBMP-2). Rev Clin Pesq Odontol. 2008; 4(3):129-36.
Lourenço Neto N, Marques NC, Fernandes AP, Rodini CO, Sakai VT, Abdo RCC, et al. Immunolocalization of dentin matrix protein-1 in human primary teeth treated with different pulp capping materials. J Biomed Mater Res B Appl Biomater. 2016; 104(1):165-9. Doi:10.1002/jbm.b.33379
Neto NL, Moretti ABS, Sakai VT, Machado MAAM, Abdo RCC, Oliveira TM. Clinical and radiographic outcomes of the use of capping materials in vital pulp therapy of human primary teeth. Braz Dent Sci. 2015; 18(1):75-80. Doi: 10.14295/bds.2015.v18i1.1107
Nelson-Filho P, Venturini DP, Silva RAB da, Júnior MF, Mori LB. Agregado de trióxido mineral (MTA) e hidróxido de cálcio como materiais capeadores em pulpotomias de dentes decíduos de humanos: avaliação clínica e radiográfica. Rev Inst Ciênc Saúde. 2005; 23(3):211-6.
Oliveira TM, Moretti AB, Sakai VT, Lourenço Neto N, Santos CF, Machado MAAM, et al. Clinical, radiographic and histologic analysis of the effects of pulp capping materials used in pulpotomies of human primary teeth. Eur Arch Paediatr Dent. 2013; 14(2):65-71. Doi: 10.1007/s40368-013-0015-x
Asgary S, Eghbal MJ. Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: a multi-center randomized controlled trial. Acta Odontol Scand. 2013; 71(1):130-6. Doi: 10.3109/00016357.2011.654251
Nosrat A, Seifi A, Asgary S. Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Int J Paediatr Dent. 2013; 23(1):56-63. Doi: 10.1111/j.1365-263X.2012.01224.x
Nosrat A, Peimani A, Asgary S. A preliminary report on histological outcome of pulpotomy with endodontic biomaterials vs calcium hydroxide. Restor Dent Endod. 2013; 38(4):227-33. Doi: 10.5395/rde.2013.38.4.227
Çelik BN, Mutluay MS, Arıkan V, Sarı Ş. The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth. Clin Oral Investig. 2019; 23(2):661-6. Doi: 10.1007/s00784-018-2472-4
Bani M, Aktaş N, Çınar Ç, Odabaş ME. The clinical and radiographic success of primary molar pulpotomy using Biodentine™ and mineral trioxide aggregate: a 24-month randomized clinical trial. Pediatr Dent. 2017; 39(4):284-8.
Subramaniam P, Konde S, Mathew S, Sugnani S. Mineral trioxide aggregate as pulp capping agent for primary teeth pulpotomy: 2 year follow up study. J Clin Pediatr Dent. 2009; 33(4):311-4. Doi: 10.17796/jcpd.33.4.r83r38423x58h38w
Vilimek VM, Gateva N, Christof BS. Success rate of MedCem Portland cement as a pulp capping agent in pulpotomies of primary teeth. J of IMAB. 2018; 24(1):1866-71. Doi: 10.5272/jimab.2018241.1866
Zealand CM, Briskie DM, Botero TM, Boynton JR, Hu JC. Comparing gray mineral trioxide aggregate and diluted formocresol in pulpotomized human primary molars. Pediatr Dent. 2010; 32(5):393-9.
Chrepa V, Joon R, Austah O, Diogenes A, Hargreaves KM, Ezeldeen M, et al. clinical outcomes of immature teeth treated with regenerative endodontic procedures: a San Antonio study. J Endod. 2020; 46(8):1074-84. Doi: 10.1016/j.joen.2020.04.008
Brannstrom M. The hydrodynamic theory of dentinal pain: sensation in preparations, caries, and the dentinal crack syndrome. J Endod. 1986; 12(10):453-7. Doi: 10.1016/S0099-2399(86)80198-4
Mainkar A, Kim SG. Diagnostic accuracy of 5 dental pulp tests: a systematic review and meta-analysis. J Endod. 2018; 44(5):694-702. Doi: 10.1016/j.joen.2018.01.021
Nagarathna C, Shakuntala BS, Jaiganesh I. Efficiency and reliability of thermal and electrical tests to evaluate pulp status in primary teeth with assessment of anxiety levels in children. J Clin Pediatr Dent. 2015; 39(5):447-51. Doi: 10.17796/1053-4628-39.5.447
Castellucci, A. Pulpal pathology. In: Castellucci A. Endodontics. Vol. I. Firenze: II Tridente; 2004. 354p. Cap. 7, p. 153-155.
Ahuja S, Surabhi K, Gandhi K, Kapoor R, Malhotra R, Kumar D. Comparative evaluation of success of biodentine and mineral trioxide aggregate with formocresol as pulpotomy medicaments in primary molars: an in vivo study. Int J Clin Pediatr Dent. 2020; 13(2):167-73. Doi: 10.5005/jp-journals-10005-1740
Yoldaş SE, Bani M, Atabek D, Bodur H. Comparison of the potential discoloration effect of bioaggregate, biodentine, and white mineral trioxide aggregate on bovine teeth. In: Vitro research. J Endod. 2016; 42(12):1815-8. Doi: 10.1016/j.joen.2016.08.020
Safavi K, Nakayama TA. Influence of mixing vehicle on dissociation of calcium hydroxide in solution. J Endod. 2000; 26(11):649-51. Doi: 10.1097/00004770-200011000-00004
Nosrat IV, Nosrat CA. Reparative hard tissue formation following calcium hydroxide application after partial pulpotomy in cariously exposed pulps of permanent teeth. Int Endod J. 1998; 31(3):221-6. Doi: 10.1046/j.1365-2591.1998.00147.x
Peng L, Ye L, Guo X, Tan H, Zhou X, Wang C, et al. Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis. Int Endod J. 2007; 40(10):751-7. Doi: 10.1111/j.1365-2591.2007.01288.x
Húngaro Duarte MA, de Oliveira El Kadre GD, Vivan RR, Guerreiro Tanomaru JM, Tanomaru Filho M, de Moraes IG. Radiopacity of Portland cement associated with different radiopacifying agents. J Endod. 2009; 35(5):737-40. Doi: 10.1016/j.joen.2009.02.006
Agência Nacional de Vigilância Sanitária (BR). ANVISA [Internet]. [citado em 2021 jul. 20]. Disponível em: http://portal.anvisa.gov.br/wps/portal/anvisa/anvisa/home.
Soares IJ, Goldberg F. Endodontia: técnicas e fundamentos. 2. ed. Artmed; 2011.
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Derechos de autor 2023 Vitória Batista Clemente, Lara Martins Araújo, Vívian Gonçalves Carvalho Souza, Laísa Araújo Cortines Laxe, Mariana Simões Oliveira, Ana Carolina Morais Apolônio
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