VITAMINA D, SOBREPESO E OBESIDADE – UMA REVISÃO

Autores

  • NATHERCIA PERCEGONI Departamento de Nutrição UFJF – Universidade Federal de Juiz de Fora ICB – Instituto de Ciências Biológicas DN – Departamento de Nutrição Bairro Martelos – Juiz de Fora – MG CEP 36036–330 Tel – (32) 2102-3234/R:28
  • Juciane Maria de Andrade Castro Departamento de Parasitologia, Microbiologia e Imunologia UFJF – Universidade Federal de Juiz de Fora ICB – Instituto de Ciências Biológicas Bairro Martelos – Juiz de Fora – MG CEP 36036–330

Resumo

Este é um estudo descritivo na modalidade de revisão bibliográfica em bases de dados, tendo, como descritores, Vitamina D, Obesidade e Sobrepeso. Objetivou-se buscar, nas bases eletrônicas de dados LILACS, MEDLINE, SCIELO, a vitamina D como temática nos trabalhos entre 1978 e 2014. A vitamina D é um hormônio esteróide com efeitos biológicos que vão além da regulação do metabolismo ósseo. Sua forma ativa é a 1,25(OH)2D3 ou calcitriol, resultante da hidroxilação da 25OHD nos tecidos. A forma 25 (OH) D ou calcifediol é a predominante no sangue e reflete a homeostase desta vitamina no organismo. Os valores sanguíneos de referência têm sido amplamente discutidos, situando-se, na maioria dos estudos, entre 80 a 100nmol/l. Atualmente, a deficiência de vitamina D tem sido considerada um problema de saúde pública, por suas implicações no desenvolvimento de diversas doenças, entre elas o sobrepeso e a obesidade. Vitamina D exerce efeito na obesidade através do receptor de vitamina D, dos receptores do tipo Toll, de prostaglandinas, enzimas como óxido nítrico sintase e das espécies reativas de oxigênio. Indivíduos obesos invariavelmente apresentam concentrações plasmáticas inferiores de vitamina D e são menos responsivos à suplementação desta vitamina, principalmente quando concentrações menores são utilizadas. Contudo, a suplementação não tem se mostrado eficaz em contribuir para a perda de peso corporal, apesar de ser efetiva para a melhoria de alguns parâmetros inflamatórios. Em conclusão, são necessários mais estudos que relacionem vitamina D e obesidade no sentido de definir as concentrações ideais desta na circulação, bem como para suplementação.

PALAVRAS-CHAVE: Vitamina D. Obesidade. Metabolismo. Alimentação.

 

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Biografia do Autor

NATHERCIA PERCEGONI, Departamento de Nutrição UFJF – Universidade Federal de Juiz de Fora ICB – Instituto de Ciências Biológicas DN – Departamento de Nutrição Bairro Martelos – Juiz de Fora – MG CEP 36036–330 Tel – (32) 2102-3234/R:28

Possui graduação em Nutrição pela Universidade Federal de Viçosa (1999), Mestrado em Bioquímica pela Universidade Federal de Viçosa (2002), Doutorado em Ciências - Fisiologia pela Universidade Federal do Rio de Janeiro (2006), Pós-doutorado em Fisiopatologia Clínica e Experimental pela Universidade Estadual do Rio de Janeiro (2011) e Pós-Doutorado em Nutrição (PNPD) pelo Instituto de Nutrição Josué de Castro/UFRJ. É pesquisadora do grupo cadastrado no CNPq: Processamento de Frutas e Hortaliças, subgrupo: Alimentos Funcionais e Dietéticos-UFRJ. Atualmente é Professora Adjunta na Universidade Federal de Juiz de Fora. Tem experiência na área de Nutrição, com ênfase em Nutrição e Dietética, Nutrição Clínica (Nutrição Clínica Clássica, Nutrição Clínica Funcional e Nutrição Clínica Estética) e Técnica Dietética.

Juciane Maria de Andrade Castro, Departamento de Parasitologia, Microbiologia e Imunologia UFJF – Universidade Federal de Juiz de Fora ICB – Instituto de Ciências Biológicas Bairro Martelos – Juiz de Fora – MG CEP 36036–330

Possui graduação em Nutrição pela Universidade Federal de Ouro Preto (2003), mestrado em Ciências Biológicas pela Universidade Federal de Ouro Preto (2005), Doutorado em Imunologia pela Universidade de São Paulo (2010) e Pos-doutorado em Toxinologia pelo Instituto Butantan (2014). Atualmente e professora Adjunta da Universidade Federal de Juiz de Fora. Tem experiência em pesquisa na área de Imunologia, atuando principalmente nos seguintes temas: Anticorpos Monoclonais e Recombinantes e Soroterapia; Controle Nervoso da Resposta Inflamatória Alérgica; Resposta Imunológica a Parasitas e Probióticos

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2015-08-20

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PERCEGONI N, Castro JM de A. VITAMINA D, SOBREPESO E OBESIDADE – UMA REVISÃO. hu rev [Internet]. 20º de agosto de 2015 [citado 2º de outubro de 2022];40(3 e 4). Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/2456

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