VITAMINA D, SOBREPESO E OBESIDADE – UMA REVISÃO
Resumo
Este é um estudo descritivo na modalidade de revisão bibliográfica em bases de dados, tendo, como descritores, Vitamina D, Obesidade e Sobrepeso. Objetivou-se buscar, nas bases eletrônicas de dados LILACS, MEDLINE, SCIELO, a vitamina D como temática nos trabalhos entre 1978 e 2014. A vitamina D é um hormônio esteróide com efeitos biológicos que vão além da regulação do metabolismo ósseo. Sua forma ativa é a 1,25(OH)2D3 ou calcitriol, resultante da hidroxilação da 25OHD nos tecidos. A forma 25 (OH) D ou calcifediol é a predominante no sangue e reflete a homeostase desta vitamina no organismo. Os valores sanguíneos de referência têm sido amplamente discutidos, situando-se, na maioria dos estudos, entre 80 a 100nmol/l. Atualmente, a deficiência de vitamina D tem sido considerada um problema de saúde pública, por suas implicações no desenvolvimento de diversas doenças, entre elas o sobrepeso e a obesidade. Vitamina D exerce efeito na obesidade através do receptor de vitamina D, dos receptores do tipo Toll, de prostaglandinas, enzimas como óxido nítrico sintase e das espécies reativas de oxigênio. Indivíduos obesos invariavelmente apresentam concentrações plasmáticas inferiores de vitamina D e são menos responsivos à suplementação desta vitamina, principalmente quando concentrações menores são utilizadas. Contudo, a suplementação não tem se mostrado eficaz em contribuir para a perda de peso corporal, apesar de ser efetiva para a melhoria de alguns parâmetros inflamatórios. Em conclusão, são necessários mais estudos que relacionem vitamina D e obesidade no sentido de definir as concentrações ideais desta na circulação, bem como para suplementação.
PALAVRAS-CHAVE: Vitamina D. Obesidade. Metabolismo. Alimentação.
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Referências
AGARWAL, A.; GUPTA, S. K.; SUKUMAR, R. Hyperparathyroidism and Malnutrition with Severe Vitamin D Deficiency. World J Surg, Lucknow, v. 33, n. 11, p. 2303-2313, nov. 2009. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/19404706>.
AHMAD, R. et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. Journal of Inflammation, Dasman, v. 9, n. 48, nov. 2012. Cited in: < http://www.journal-inflammation.com/content/9/1/48>.
AKIRA, S.; TAKEDA, K. Toll-like receptor signalling. Nature Reviews Immunology, Osaka, v. 4, n. 7, p. 499-511, jul. 2004. Cited in: < http://www.nature.com/nri/journal/v4/n7/full/nri1391.html>.
APARNA, R. et al. Selective inhibition of cyclooxygenase-2 (COX-2) by 1 α,25-dihydroxy- 16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog. Journal of Cellular Biochemistry, Hyderabad, v. 104, n. 5, p. 1832–1842, august. 2008. Cited in: < http://onlinelibrary.wiley.com/doi/10.1002/jcb.21749/abstract>.
BABIOR, B. M. Oxygen-dependent microbial killing by phagocytes (second of two parts). The New England Journal of Medicine, Boston, v. 298, n. 13, p. 721-725, mar. 1978. Cited in: < http://www.nejm.org/doi/full/10.1056/NEJM197803302981305>.
BABIOR, B. M. NADPH oxidase: an update. Blood, La Jolla, v. 93, n. 5, p. 1464-1476, mar. 1999. Cited in: < http://www.bloodjournal.org/content/93/5/1464?sso-checked=true>.
BABIOR, B. M. Phagocytes and oxidative stress. American Journal of Medicine, La Jolla, v. 109, n. 1, p. 33-44, jul. 2000. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/10936476>.
BINH, T. Q. et al. Correlations between genetic variance and adiposity measures, and gene x gene interactions for obesity in postmenopausal Vietnamese women. Journal of Genetics, Hanoi, v. 90, n. 1, p. 1–9, april. 2011. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/21677383>.
BLACKBURN, G. L.; WOLLNER, S.; HEYMSFIELD, S. B. Lifestyle interventions for the treatment of class III obesity: a primary target for nutrition medicine in the obesity epidemic. American Journal of Clinical Nutrition, Boston, v. 91, n. 1, p. 289S-292S, jan. 2010. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/19906805>.
BOKOCH, G. M.; KNAUS, U. G. NADPH oxidases: not just for leukocytes anymore! Trends in Biochemical Sciences, La Jolla, v. 28, n. 9, p. 502-508, sep. 2003. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/13678962>
BONDIA-PONS, I.; RYAN, L.; MARTINEZ, J. A. Oxidative stress and inflammation interactions in human obesity. Journal Physiology and Biochemistry, Pamplona, v. 68, n. 4, p. 701–711, dec. 2012. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22351038>.
CHANCE, B.; SIES, H.; BOVERIS, A. Hydroperoxide metabolism in mammalian organs. Physiological Reviews, Filadélfia, v. 59, n. 3, p. 527-605, jul. 1979. Cited in: <http://physrev.physiology.org/content/59/3/527>
CHANG, J. M. et al. 1-α,25- Dihydroxyvitamin D3 regulates inducible nitric oxide synthase messenger RNA expression and nitric oxide release in macrophage-like RAW264. 7 cells. Journal of Laboratory Clinical Medicine, Kaohsiung, v. 143, n. 1, p.14–22, jan. 2004. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/14749681>.
CODOÑER-FRANCH, P. et al. Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Translational Ressearch, Valencia, v. 158, n. 6, p. 369–384, dec. 2011. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/22061044>
CONNER, E. M.; GRISHAM, M. B. Inflammation, free radicals, and antioxidants. Nutrition, Shreveport, v. 12, n. 4, p. 274-7, Apr. 1996. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/8862535>
CREELY, S. J. et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. American Journal of Physiology Endocrinology and Metabolism, Coventry, v. 292, n. 3, p. E740–E747, mar. 2007. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/17090751>.
DAVIES, K. J. Oxidative stress: the paradox of aerobic life. Biochemical Society Symposia, New York, Albany, v. 61, n. 1, p. 1-31, 1995. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/8660387>
DEAN, D. D. et al. Vitamin D regulation of metalloproteinase activity in matrix vesicles. Connective Tissue Research, San Antonio, v. 35, n. 1-4, p. 331–336, 1996. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/9084672>
FITZPATRICK, S.; JOKS, R.; SILVERBERG, J. I. Obesity is associated with increased asthma severity and exacerbations, and increased serum immunoglobulin E in inner-city adults. Clinical & Experimental Allergy, New York, v. 42, n. 5, p. 747-759, mai. 2012. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22092883>
FREEMAN, L. R. et al. Obesity increases cerebrocortical reactive oxygen species and impairs brain function. Free Radical Biology & Medicine, Baton Rouge, v. 56, p. 226-33, mar. 2013. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/23116605>
FUJITANI, Y. et al. Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. FEBS Journal, Osaka, v. 277, n. 6, p. 1410–1419, mar. 2010. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/20136655>
GALLAGHER, J. C.; YALAMANCHILI, V.; SMITH, L. M. The effect of vitamin D supplementation on serum 25OHD in thin and obese women. Journal of Steroid Biochemistry & Molecular Biology, Omaha, v. 13, p. 195–200, jul. 2013. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/23246640>
GARVIN, P. et al. Circulating matrix metalloproteinase-9 is associated with cardiovascular risk factors in a middle-aged normal population. PLOS One, Linkoping, v. 3, p. 1774, mar. 2008. Cited in: < http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001774>
GHOSHAL, S. et al. Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice. The Journal of Biological Chemistry, Lexington, v. 286, n. 1, p. 889–898, jan, 2011. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/20961858>
GOYAL, R.; SINGHAI, M.; FAIZY, A. F. Glutathione peroxidase activity in obese and nonobese diabetic patients and role of hyperglycemia in oxidative stress. Journal Midlife Health, Haldwani, v. 2, n. 2, p. 72–76, jul. 2011. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22408335>
GRANT, W.B.; HOLICK, M. F. Benefits and requirements of vitamin D for optimal health: a review. Alternative Medicine Review, San Francisco, v. 10, n. 2, p. 94-111, jun. 2005. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/15989379>
GRANT, W. B. Benefits of ultraviolet-B irradiance and vitamin D in youth. Journal of Steroid Biochem & Molecular Biology, San Francisco, v. 136, p. 221–223, jul. 2012. Cited in: < http://www.sciencedirect.com/science/article/pii/S0960076012002038>
GREENBERG, A. S.; OBIN, M. S. Obesity and the role of adipose tissue in inflammation and metabolism. The American Journal of Clinical Nutrition, Boston, v. 83, n. 2, p. 461S-465S, fev. 2006. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/16470013>
GRIMBLE, R. F. The true cost of in-patient obesity: impact of obesity on inflammatory stress and morbidity. Proceeding of the Nutrition Society, Southampton, v. 69, n. 4, p. 511-517, nov. 2010. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/20598196>
GUYTON, K. Z.; KENSLER, T. W.; POSNER, G. H. Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutrition Reviews, Mountain View, v. 61, n. 7, p. 227-238, jul. 2003. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/12918875>
GUZEY, M. et al. Increased apoptosis of periprostatic adipose tissue in VDR null mice. Journal of Cellular Biochemistry, Pittsburgh, v. 93, n. 1, p. 133–141, set. 2004. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/15352170>
HASHIZUME, K. et al. Effect of active vitamin D3 on the levels of NADPH-dependent cytosolic 3,5,3′-triiodo-L´thyronine-binding protein. Biochemical and Biophysical Research Communications, Matsumoto, v. 177, n. 1, p. 388–394, mai. 1991. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/2043122>
HENKEL, J. et al. Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis. Laboratory Investigation, Nuthetal, v. 92, n. 11, p. 1597–1606, nov. 2012. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/22964849>
HOLICK, M. F. Sunlight and vitamin D for bone health and preventions of autoimmune diseases, cancers, and cardiovascular disease. The American Journal Clinical Nutrition, Boston, v. 80, n. 6 supplement, p. 1678S-1688S, dec. 2004. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/15585788>
HOLICK, M. F. High prevalence of vitamin D inadequacy and implications for health. Mayo Clinic Proceedings, Boston, v. 81, n. 3, p. 353-373, mar. 2006. Cited in: > http://www.ncbi.nlm.nih.gov/pubmed/16529140
JIANG, F. et al. Systemic upregulation of NADPH oxidase in diet-induced obesity in rats. Redox Report, Melbourne, v. 16, n. 6, p. 223–229, nov. 2011. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22195989>
KANNEGANTI, T. D.; DIXIT V. D. Immunological complications of obesity. Nature Immunology, Memphis, v. 13, n. 8, p. 707-712, jul. 2012. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22814340>
KARLSSON, E. A.; BECK, M. A. The burden of obesity on infectious disease. Experimental Biology and Medicine, Memphis, v. 235, n. 12, p. 1412-142, dec. 2010. Cited in:
http://www.ncbi.nlm.nih.gov/pubmed/21127339>
KIM, S. J. et al. Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice. The journal of Nutritional Biochemistry, Seoul, v. 23, n. 2, p. 113-122, feb. 2012. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/21414767>
KIMBALL, S.; FULEIHAN, G. H.; VIETH, R. Vitamin D: a growing perspective. Critical Reviews in Clinical Laboratory Sciences, Toronto, v. 45, n. 4, p. 339-414, 2008. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/18568854>
KOK, J. et al. Viral Pneumonitis Is Increased in Obese Patients during the First Wave of Pandemic A(H1N1) 2009 Virus. PLOS One, Sydney, v. 8, n. 2, p. e55631, fev. 2013. Cited in: <http://www.plosone.org/article/authors/info%3Adoi%2F10.1371%2 Fjournal.pone.0055631>
LAIMER, M. et al. Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women. International Journal Obesity, Innsbruck, v. 29, n. 5 p. 498–501, mai. 2005. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/15685246>
LAPPE, J. The Role of Vitamin D in Human Health: A Paradigm Shift. Journal of Evidence-Based Complementary & Alternative Medicine, Omaha, v. 16, n. 1, p. 58-72, jan. 2011. Cited in: <http://chp.sagepub.com/content/16/1.toc>
LEBLANC, E. at al. Associations Between 25-Hydroxyvitamin D and Weight Gain in Elderly Women. Journal of Women's Health, Portland, v. 1, n. 10, p. 1066-73, out. 2012. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22731629>
LEFEBVRE, P. et al. Nutrient deficiencies in patients with obesity considering bariatric surgery: a cross-sectional study. Surgery of Obesity and Related Diseases, Montpellier, v. 13, n. 3, p. 540-546, mai/jun 2014. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/24630922>
LEVY, R.; MALECH, H. L. Effect of 1,25-dihydroxyvitamin D3, lipopolysaccharide, or lipoteichoic acid on the expression of NADPH oxidase components in cultured human monocytes. The Journal of Immunology, Beer-Sheva, v.147, n. 9, p. 3066–3071, nov. 1991. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/1655903>
LIN, R.; WHITE, J. H. The pleiotropic actions of vitamin D. Bioessays, Montreal, v. 26, n. 1, p. 21-8, jan. 2004. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/14696037>
LIU, P. T. et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science, Los Angeles, v. 311, n. 5.768, p. 1770–1773, mar. 2006. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/16497887>
LYON, C. J.; LAW, R. E.; HSUEH, W. A. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology, Los Angeles, v. 144, n. 6, p. 2195–2200, jun. 2003. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/12746274>
MASON, C. et al. Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial. The American Journal of Clinical Nutrition, Washintong, v. 99, n. 5, p. 1015-1025, mar. 2014. Cited in: < http://ajcn.nutrition.org/content/99/5.toc>
MIKSZTOWICZ, V. et al. Increase in MMP-2 activity in overweight and obese women is associated with menopausal status. Climacteric, Buenos Aires, v. 15, n. 6, p. 602–606, dec. 2012. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22642972>.
MILLER, W. L.; PORTALLE, A. A. Genetic Disorders of vitamin D Biosynthesis. International Journal of Pediatric Endocrinology, San Francisco, v.28, n. 4, p. 825-840, dec. 1999. Cited in: http://www.ncbi.nlm.nih.gov/pubmed/10609122
MILOVANOVIC, M. et al. A Deficiência de vitamina D está associada com níveis aumentados de IL-17 e TNF-α em pacientes com insuficiência cardíaca crônica. Arquivos Brasileiros De Cardiologia, Niska Banja, v. 98, n. 3, p. 259-264, dec. 2011. Cited in: < http://www.arquivosonline.com.br/2012/9803/home.asp>.
MORENO, J. et al. Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. Cancer Research, Stanford, v. 65, n. 17, p. 7917–7925, set. 2005. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/16140963>
NORMAN, A. W. From vitamin D to hormone D: Fundamentals of the vitamina D endocrine system essential for good health. The American Journal of Clinical Nutrition, Riverside, v. 88, n. 2, p. 491S-499S, august. 2008. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/18689389>
OJAIMI, S. et al. Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: A pilot study. Journal of Translational Medicine, Victoria, v. 11, n. 1, p. 176, julho. 2013. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/23875738
PAUSOVA, Z. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Current Opinion in Nephrology and Hypertension, Nottingham, v. 15, n. 2, p. 173-178, mar. 2006. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/16481885>
REYNA, S. M. et al. Elevated toll-like receptor 4 expression and signaling in muscle from insulin resistant subjects. Diabetes, San Antonio, v. 57, n. 10, p. 2595–2602, out. 2008. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/18633101>
RONCHI, F. C.; SONAGLI, M. RONCHI, M. G. C. Prevalência de Hipovitaminose D em população de consultório médico. Revista do Médico Residente, Curitiba, v. 14, n. 3, p. 173-180, jul/set. 2012. Cited in: < http://www.crmpr.org.br/publicacoes/cientificas/index.php/revista-do medicoresidente/article/view/264/252>
ROOS, D.; VAN BRUGGEN, R.; MEISCHL, C. Oxidative killing of microbes by neutrophils. Microbes and Infection, Amsterdam, v. 5, n. 14, p. 1307-1315, Nov. 2003. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/14613774>
ROTH, C. L. et al. Vitamin D deficiency in obese rats exacerbates NAFLD and increases hepatic resistin and toll-like receptor activation. Journal of Hepatology, Washington, v. 55, n. 4, p. 1103–1111, abril. 2012. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/21994008>
SADEGHI, K. et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. European Journal Immunology, Vienna, v. 36, n. 2, p. 361–370, fev. 2006. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/16402404>
SAMUVEL, D. J. et al. Adipocytemononuclear cell interaction, Toll-like receptor 4 activation, and high glucose synergistically up-regulate osteopontin expression via an interleukin 6-mediated mechanism. The Journal of Biological Chemistry, Sharleston, v. 285, n. 6, p. 3916–3927, feb. 2010. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/20007708>
SCHUCH, N. J.; GARCIA, V. C.; MARTINI, L. A. Vitamina D e doenças endocrinometabólicas. Arquivos Brasileiros De Endocrinologia & Metabologia, São Paulo, v. 53, n. 5, p. 625-633, abril. 2009. Cited in: < http://www.scielo.br/scielo.php?script=sci_issuetoc&pid=0004-273020090005&lng=en&nrm=iso>
SHI, H. et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. The Journal of Clinical Investigation, Boston, v. 116, n. 11, p. 3015–3025, nov. 2006. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/17053832>
SHOELSON, S. E.; LEE, J.; GOLDFINE, A. B. Inflammation and insulin resistance. The Journal of Clinical Investigation, Boston, v. 116, n. 7, p. 1793–1801, jul. 2006. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/16823477>
SONG, M. J. et al. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochemical and Biophysical Research Communication, Seoul, v. 346, n. 3, p. 739–745, agosto. 2006. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/16781673>
SOSKIĆ, S.; STOKIĆ, E.; ISENOVIĆ, E. R. The relationship between vitamin D and obesity. Current Medical Research & Opinion, Belgrade, v.30, n. 6, p. 1197-1199. Jun. 2014. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/24640937>
STOKIĆ, E. et al. Obesity and Vitamin D Deficiency: Trends to Promote a More Proatherogenic Cardiometabolic Risk Profile. Angiology, Novi Sad, v. 65 , n.3 , p. 1-7B, mar. 2014. Cited in: < http://ang.sagepub.com/content/early/2014/03/20/0003319714528569.full>
SUTTON, A. L.; MCDONALD, P. N. Vitamin D: more than a “bone-a-fide” hormone. Molecular Endocrinology, Cleveland, v. 17, n. 5, p. 777-791, mai. 2003. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/12637589>
SU, X.; ZEMEL, M. B. 1 alpha, 25-dihydroxyvitamin D and corticosteroid regulate adipocyte nuclear vitamin D receptor. International Journal Obesity, Knoxville, v. 32, n. 8, p. 1305-1311, agosto. 2008. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/18427562>
TETICH, M. et al. Neuroprotective effects of (24R)-1,24-dihydroxycholecalciferol in human neuroblastoma SH-SY5Y cell line. The Journal of Steroid Biochemistry Molecular Bioly, Kraków, v. 89, n. 90, p. 365–370, mai. 2004. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/15225802>
TISSANDIE, E. et al. Vitamin D: metabolism, regulation et maladies associées. Médecine/sciences, Paris, v. 22, n. 12, p. 1095-1100, Dec. 2006. Cited in: < http://www.medecinesciences.org/articles/medsci/abs/2006/11/medsci20062212p1095/medsci20062212p1095.html>
TRUDLER, D.; FARFARA, D.; FRENKEL, D. Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application. Mediators of Inflammations, Tel Aviv Yafo, v. 2010, p. 1–12, jun. 2010. Cited in: < http://www.hindawi.com/journals/mi/2010/497987/>
TSAN, M. F.; GAO, B. Endogenous ligands of Toll-like receptors. Journal of Leukocyte Biology, Washington, v. 76, n. 3, p. 514–519, set. 2004. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/15178705>
TSUCHIYA, K. et al. Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice. Endocrinology, Tókio, v. 148, n. 10, p. 4548–4556, out. 2007. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/17584959>
VAN DE SANDE-LEE, S.; VELLOSO, L. A. Disfunção hipotalâmica na obesidade. Arquivos Brasileiros de Endocrinologia e Metabologia, São Paulo, v. 56, n. 6, p. 341-350, augusto. 2012. Cited in: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000600001&lng=en&nrm=iso&tlng=pt>
VASILOPOULOS, Y. et al. VDR TaqI is associated with obesity in the Greek population. Gene, Larissa, v. 512, n. 2, p. 237–239, jan. 2013. Cited in: < http://www.ncbi.nlm.nih.gov/pubmed/23103831>
VIETH, R.; LADAK, Y.; WALSH, P. G. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. The Journal of Clinical Investigation, Toronto, v. 88, n. 1, p. 185-91, jan. 2003. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/12519850>
YE, W. Z. et al. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. European Journal of Endocrinology, Paris, v. 145, n. 2, p. 181–186, august. 2001. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/11454514>
WAMBERG, L. et al. Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels — Results from a randomized trial. European Journal of Internal Medicine, Aarhus, v. 24, n. 7, p. 644-49, out. 2013. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/23566943>
WEBER, K.; ERBEN, R. G. Differences in triglyceride and cholesterol metabolism and resistance to obesity in male and female vitamin D receptor knockout mice. Journal of Animal Physiology and Animal Nutrition, Muenchen, v. 97, n. 4, p. 675-83, Aug. 2013. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/22548652>
WEISBERG, S. P. et al. Obesity is associated with macrophage accumulation in adipose tissue. The Journal of Clinical Investigation, New York, v. 112, n. 12, p. 1796-1808, dec. 2003. Cited in:< http://www.ncbi.nlm.nih.gov/pubmed/14679176>
WELLEN, K. E.; HOTAMISLIGIL, G. S. Obesity-induced inflammatory changes in adipose tissue. The Journal of Clinical Investigation, Boston, v. 112, n. 12, p. 1785-1788, dec. 2003. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/14679172>
ZINZER, G. M.; WELSH, J. E. Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Carcinogenesis, Notre Dame, v. 25, n. 12, p. 2361–2372, dec. 2004. Cited in: <http://www.ncbi.nlm.nih.gov/pubmed/15333467>
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