Visión espacial en el tratamiento del cáncer de mama: reporte de caso
DOI:
https://doi.org/10.34019/1982-1247.2025.v19.43348Palabras clave:
Neoplasias mamarias, Tratamiento antineoplástico, Procesamiento visual, VisiónResumen
Presentamos el caso de una mujer brasileña de 48 años con cáncer de mama en tratamiento antineoplásico, a quien se le evaluó contraste y visión de colores: (1) después de quimioterapia; (2) seis meses después de la quimioterapia, utilizando terapia hormonal diaria. Algunas frecuencias espaciales y ejes cromáticos mostraron mejores umbrales seis meses después del final del tratamiento de quimioterapia. El estudio evaluó el procesamiento visual de una mujer con cáncer de mama, controlando el efecto de las interacciones entre medicamentos antineoplásicos. Se necesitan estudios adicionales para comprender mejor cómo el tratamiento antineoplásico afecta la sensibilidad visual.
Descargas
Citas
Abdelhadi, O. (2023). The impact of psychological distress on quality of care and access to mental health services in cancer survivors. Frontiers in Health Services, 3, 1111677. https://doi.org/10.3389/frhs.2023.1111677
Adams, R. J., & Courage, M. L. (2002). Using a single test to measure human contrast sensitivity from early childhood to maturity. Vision Research, 42(9), 1205–1210. https://doi.org/10.1016/S0042-6989(02)00038-X
Ahles, T. A., & Saykin, A. J. (2007). Candidate mechanisms for chemotherapy-induced cognitive changes. Nature Reviews Cancer, 7(3), 192–201. https://doi.org/10.1038/nrc2073
Almeida, S., Camacho, M., Barahona-Corrêa, J. B., Oliveira, J., Lemos, R., Silva, D. R., Silva, J. A., Baptista, T. M., Grácio, J., & Oliveira-Maia, A. J. (2023). Criterion and construct validity of the Beck Depression Inventory (BDI-II) to measure depression in patients with cancer: The contribution of somatic items. International Journal of Clinical and Health Psychology, 23(2), 100350. https://doi.org/10.1016/j.ijchp.2022.100350
American Cancer Society. (2019). Hormone Therapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-reast-cancer.html
Anderson, D. E., Holstein, S. A., & Kedar, S. (2020). Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and directions for future research. Neuro-Ophthalmology, 44(3), 139–147. https://doi.org/10.1080/01658107.2019.1702703
Beck, A. T., & Steer, R. A. (1990). Manual for the Beck anxiety inventory. Psychological Corporation.
Beck, A. T., Steer, R. A., & Brown, G. (1996). BDI-II: Beck Depression Inventory Manual. Psychological Corporation.
Bolukbasi, S., Ozge, K. G., Cakir, A., Erden, B., & Karatas, G. (2020). Retinal structural changes in patients receiving tamoxifen therapy by spectral-domain optical coherence tomography. Cutaneous and Ocular Toxicology, 39(2), 115–121. https://doi.org/10.1080/15569527.2020.1734816
Burkhardt, D. A., & Fahey, P. K. (1999). Contrast rectification and distributed encoding by on-off amacrine cells in the retina. Journal of Neurophysiology, 82(4), 1676–1688. https://doi.org/10.1152/jn.1999.82.4.1676
Burstein, H. J., Lacchetti, C., Anderson, H., Buchholz, T. A., Davidson, N. E., Gelmon, K. A., Giordano, S. H., Hudis, C. A., Solky, A. J., Stearns, V., Winer, E. P., & Griggs, J. J. (2019). Adjuvant endocrine therapy for women with hormone receptor–positive breast cancer: ASCO clinical practice guideline focused update. Journal of Clinical Oncology, 37(5), 423–438. https://doi.org/10.1200/JCO.18.01160
Campbell, F. W., & Maffei, L. (1974). Contrast and spatial frequency. Scientific American, 231(5), 106–114. https://doi.org/10.1038/scientificamerican1174-106
Cardoso, C. V., Barros, M. P., Bachi, A. L. L., Bernardi, M. M., Kirsten, T. B., Martins, M. F. M., Rocha, P. R. D., Rodrigues, P. S., & Bondan, E. F. (2020). Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration. Behavioural Brain Research, 378, 112233. https://doi.org/10.1016/j.bbr.2019.112233
Chan, C. W. H., Law, B. M. H., So, W. K. W., Chow, K. M., & Waye, M. M. Y. (2020). Pharmacogenomics of breast cancer: Highlighting CYP2D6 and tamoxifen. Journal of Cancer Research and Clinical Oncology, 146(6), 1395–1404. https://doi.org/10.1007/s00432-020-03206-w
Chelala, E., Arej, N., Antoun, J., Kourie, H. R., Zaarour, K., Haddad, F. G., Farhat, F., El Karak, F., & Kattan, J. (2017). Central Macular Thickness monitoring after a Taxane-Based Therapy in Visually Asymptomatic Patients. Chemotherapy, 62(3), 199–204. https://doi.org/10.1159/000456653
Chiang, J. C. B., Goldstein, D., Trinh, T., Au, K., Park, S. B., Krishnan, A. V., & Markoulli, M. (2021). A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer. Scientific Reports, 11(1), 1786. https://doi.org/10.1038/s41598-021-81398-y
Delanaye, P., Vidal-Petiot, E., Björk, J., Ebert, N., Eriksen, B. O., Dubourg, L., Grubb, A., Hansson, M., Littmann, K., Mariat, C., Melsom, T., Schaeffner, E., Sundin, P.-O., Bökenkamp, A., Berg, U. B., Åsling-Monemi, K., Åkesson, A., Larsson, A., Cavalier, E., … Flamant, M. (2023). Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa. Nephrology Dialysis Transplantation, 38(1), 106–118. https://doi.org/10.1093/ndt/gfac241
Eisner, A. (2004). Short wavelength automated peperimetry and tamoxifen use. British Journal of Ophthalmology, 88(1), 125–130. https://doi.org/10.1136/bjo.88.1.125
Eisner, A., & Incognito, L. J. (2006). The color appearance of stimuli detected via short-wavelength-sensitive cones for breast cancer survivors using tamoxifen. Vision Research, 46(11), 1816–1822. https://doi.org/10.1016/j.visres.2005.11.003
Eisner, A., & Luoh, S. W. (2011). Breast cancer medications and vision: Effects of treatments for early-stage disease. Current Eye Research, 36(10), 867–885. https://doi.org/10.3109/02713683.2011.594202
Enzsoly, A., Kammerer, K., Nemeth, J., & Schneider, M. (2015). Bilateral cystoid macular edema following docetaxel chemotherapy in a patient with retinitis pigmentosa: A case report. BMC Ophthalmology, 15(1), 32. https://doi.org/10.1186/s12886-015-0020-4
Fernandes, T. P., Andrade, S. M., Andrade, M. J. O., Nogueira, R. M. T. B. L., & Santos, N. A. (2017). Colour discrimination thresholds in type 1 Bipolar Disorder: A pilot study. Scientific Reports, 7(1), 16405. https://doi.org/10.1038/s41598-017-16752-0
Fernandes, T. P., Butler, P. D., Rodrigues, S. J., Silva, M., Anchieta, M. V., Souto, J. J. S., Gomes, G. H. V., Almeida, N. L., & Santos, N. A. (2020). Short-term effects of nicotine gum on facial detection in healthy nonsmokers: A pilot randomized controlled trial. Journal of Addictive Diseases, 39(1), 15–25. https://doi.org/10.1080/10550887.2020.1805093
Fernandes, T. P., Silverstein, S. M., Almeida, N. L., & Santos, N. A. (2018). Psychophysical evaluation of contrast sensitivity using Gabor patches in tobacco addiction. Journal of Clinical Neuroscience, 57, 68–73. https://doi.org/10.1016/j.jocn.2018.08.034
Fernandes, T. P., Silverstein, S. M., Almeida, N. L., & Santos, N. A. (2019). Visual impairments in type 1 bipolar disorder. The World Journal of Biological Psychiatry, 20(10), 790–798. https://doi.org/10.1080/15622975.2019.1628302
Ferroni, N. M., Chertoff, M. J., Alberca, C. D., Berardino, B. G., Gianatiempo, O., Brahamian, M., Levi, V., Urrutia, L., Falasco, G., Cánepa, E. T., & Sonzogni, S. V. (2023). Oxidative stress associated with spatial memory impairment and social olfactory deterioration in female mice reveals premature aging aroused by perinatal protein malnutrition. Experimental Neurology, 368, 114481. https://doi.org/10.1016/j.expneurol.2023.114481
Giralt, J., Rey, A., Villanueva, R., Alforja, S., & Casaroli-Marano, R. P. (2012). Severe visual loss in a breast cancer patient on chemotherapy. Medical Oncology, 29(4), 2567–2569. https://doi.org/10.1007/s12032-012-0191-2
Gorin, M. B., Day, R., Costantino, J. P., Fisher, B., Redmond, C. K., Wickerham, L., Gomolin, J. E. S., Margolese, R. G., Mathen, M. K., Bowman, D. M., Kaufmann, D., Dimitrov, N. V., Singerman, L. J., Bornstein, R., & Wolmark, N. (1998). Long-term tamoxifen citrate use and potential ocular toxicity. American Journal of Ophthalmology, 125(4), 493–501. https://doi.org/10.1016/S0002-9394(99)80190-1
Hopkins, S., & Rothwell, N. (1995). Cytokines and the nervous system. I: Expression and recognition. Trends in Neuroscience, 18(2), 82–88.
Huang, I. C., Hudson, M. M., Robison, L. L., & Krull, K. R. (2017). Differential impact of symptom prevalence and chronic conditions on quality of life in cancer survivors and non-cancer individuals: A population study. Cancer Epidemiology, Biomarkers & Prevention, 26(7), 1124–1132. https://doi.org/10.1158/1055-9965.EPI-16-1007Ibrahim, A., Toss, M. S., Atallah, N. M., Al Saleem, M., Green, A. R., & Rakha, E. A. (2023). Combined proliferation and apoptosis index provides better risk stratification in breast cancer. Histopathology, 82(7), 1029–1047. https://doi.org/10.1111/his.14887
Ishihara, S. (1964). The Series of Plates designed as a test for Colour-Blindness (24th ed). Stanford University.
Jagieła, J., Bartnicki, P., & Rysz, J. (2021). Nephrotoxicity as a complication of chemotherapy and immunotherapy in the treatment of colorectal cancer, melanoma and non-small cell lung cancer. International Journal of Molecular Sciences, 22(9), 4618. https://doi.org/10.3390/ijms22094618
Jansen, C., Miaskowski, C., Dodd, M., Dowling, G., & Kramer, J. (2005). Potential mechanisms for chemotherapy-induced impairments in cognitive function. Oncology Nursing Forum, 32(6), 1151–1163. https://doi.org/10.1188/05.ONF.1151-1163
Kaiser-Kupfer, M. I., & Lippman, M. E. (1978). Tamoxifen retinopathy. Cancer Treatment Reports, 62(3), 315–320.
Kuznetcova, T. I., Cech, P., & Herbort, C. P. (2012). The mystery of angiographically silent macular oedema due to taxanes. International Ophthalmology, 32(3), 299–304. https://doi.org/10.1007/s10792-012-9558-9
Lee, B. B., Silveira, L. C. L., Yamada, E. S., Hunt, D. M., Kremers, J., Martin, P. R., Troy, J. B., & Silva-Filho, M. (2000). Visual responses of ganglion cells of a NewWorld primate, the capuchin monkey, Cebus apella. The Journal of Physiology, 528(3), 573–590. https://doi.org/10.1111/j.1469-7793.2000.00573.x
Lee, H. S., Ha, J. Y., Choi, W., & Yoon, K. C. (2016). Bilateral corneal epithelial lesions associated with paclitaxel. Optometry and Vision Science, 93(10), 1333–1336. https://doi.org/10.1097/OPX.0000000000000945
Lomeli, N., Di, K., Czerniawski, J., Guzowski, J. F., & Bota, D. A. (2017). Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radical Biology and Medicine, 102, 274–286. https://doi.org/10.1016/j.freeradbiomed.2016.11.046
Lyon, D. E., Cohen, R., Chen, H., Kelly, D. L., McCain, N. L., Starkweather, A., Ahn, H., Sturgill, J., & Jackson-Cook, C. K. (2016). Relationship of systemic cytokine concentrations to cognitive function over two years in women with early stage breast cancer. Journal of Neuroimmunology, 301, 74–82. https://doi.org/10.1016/j.jneuroim.2016.11.002
Maier, S. F., & Watkins, L. R. (2003). Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain, Behavior, and Immunity, 17(1), 125–131. https://doi.org/10.1016/S0889-1591(02)00079-X
Mandapati, A., & Lukong, K. E. (2023). Triple negative breast cancer: Approved treatment options and their mechanisms of action. Journal of Cancer Research and Clinical Oncology, 149(7), 3701–3719. https://doi.org/10.1007/s00432-022-04189-6
Morissette, M., Le Saux, M., D’Astous, M., Jourdain, S., Al Sweidi, S., Morin, N., Estrada-Camarena, E., Mendez, P., Garcia-Segura, L. M., & Di Paolo, T. (2008). Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. The Journal of Steroid Biochemistry and Molecular Biology, 108(3–5), 327–338. https://doi.org/10.1016/j.jsbmb.2007.09.011
Noureddin, B., Seoud, M., Bashshur, Z., Salem, Z., Shamseddin, A., & Khalil, A. (1999). Ocular toxicity in low-dose tamoxifen: A prospective study. Eye, 13(6), 729–733. https://doi.org/10.1038/eye.1999.217
O’Brien, P., Young, R. C., Ghafoori, S. D., Harper, C. A., & Wong, R. W. (2019). Central serous retinopathy associated with topical oral corticosteroid use: A case report. Journal of Medical Case Reports, 13(1), 201. https://doi.org/10.1186/s13256-019-2143-3
Oliveira, M. E. C. D., Silva, G. M., Lima, E. S. H., Almeida, N. L., Fernandes, T., Negreiros, N. S., Trombetta, B. N. T., & Santos, N. A. (2023). Consequences of antineoplastic treatment on visual processing of women with breast cancer: A systematic review. Trends in Psychology, 33, 536–560. https://doi.org/10.1007/s43076-023-00289-5
Paramei, G. V., & Oakley, B. (2014). Variation of color discrimination across the life span. Journal of the Optical Society of America A, 31(4), A375. https://doi.org/10.1364/JOSAA.31.00A375
Pavlidis, N. A., Petris, C., Briassoulis, E., Klouvas, G., Psilas, C., Rempapis, J., & Petroutsos, G. (1992). Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity a prospective study of 63 patients. Cancer, 69(12), 2961–2964. https://doi.org/10.1002/1097-0142(19920615)69:12<2961::AID-CNCR2820691215>3.0.CO;2-W
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001). A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel. Pain, 94(3), 293–304. https://doi.org/10.1016/S0304-3959(01)00363-3
Raffa, R. B., & Tallarida, R. J. (2010). Effects on the visual system might contribute to some of the cognitive deficits of cancer chemotherapy-induced ‘chemo-fog’: Ocular toxicity and ‘chemo-fog’. Journal of Clinical Pharmacy and Therapeutics, 35(3), 249–255.
Roudaia, E., Bennett, P. J., Sekuler, A. B., & Pilz, K. S. (2010). Spatiotemporal properties of apparent motion perception and aging. Journal of Vision, 10(14), 5–5. https://doi.org/10.1167/10.14.5
Saligan, L. N., Olson, K., Filler, K., Larkin, D., Cramp, F., Sriram, Y., Escalante, C. P., del Giglio, A., Kober, K. M., Kamath, J., Palesh, O., & Mustian, K. (2015). The biology of cancer-related fatigue: A review of the literature. Supportive Care in Cancer, 23(8), 2461–2478. https://doi.org/10.1007/s00520-015-2763-0
Salomão, S. R., Watanabe, S. E. S., Berezovsky, A., & Motono, M. (2007). Multifocal electroretinography, color discrimination and ocular toxicity in tamoxifen use. Current Eye Research, 32(4), 345–352. https://doi.org/10.1080/02713680701229638
Santos, N. A., Andrade, S. M., & Silva, H. C. (2011). The effects of chemotherapy on the contrast sensitivity function of breast cancer patients. International Journal of Psychological Studies, 3(2), 29. https://doi.org/10.5539/ijps.v3n2p29
Sekuler, R., & Tynan, P. (1977). Rapid measurement of contrast-sensitivity functions. Optometry and Vision Science, 54(8), 573–575. https://doi.org/10.1097/00006324-197708000-00014
Silva, G. M., Almeida, N. L., Souto, J. J. S., Rodrigues, S. J., Fernandes, T. P., & Santos, N. A. (2021). Does chronic smoking affect performance on a go/no-go task? Current Psychology, 41, 7636–7644. https://doi.org/10.1007/s12144-020-01305-y
Spelsberg, H., Klueppel, M., Reinhard, T., Glaeser, M., Niederacher, D., Beckmann, M. W., & Sundmacher, R. (2004). Detection of Oestrogen receptors (ER) α and β in conjunctiva, lacrimal gland, and tarsal plates. Eye, 18(7), 729–733. https://doi.org/10.1038/sj.eye.6701314
Szabelska, P., Paczwa, K., Ciszewska, J., Różycki, R., & Gołębiewska, J. (2023). Unilateral tamoxifen-induced retinopathy as a consequence of breast cancer treatment—Multimodal imaging value. Diagnostics, 13(7), 1250. https://doi.org/10.3390/diagnostics13071250
Tang, R., Shields, J., Schiffman, J., Li, H., Locher, D., Hampton, J., Prager, T., & Pardo, G. (1997). Retinal changes associated with tamoxifen treatment for breast cancer. Eye, 11, 295–297. https://doi.org/10.1038/eye.1997.64
Therssen, R., Jansen, E., Leys, A., Rutten, J., & Meyskens, J. (1995). Screening for tamoxifen ocular toxicity: A prospective study. European Journal of Ophthalmology, 5(4), 230–234. https://doi.org/10.1177/112067219500500406
Wilson, H. R., & Humanski, R. (1993). Spatial frequency adaptation and contrast gain control. Vision Research, 33(8), 1133–1149. https://doi.org/10.1016/0042-6989(93)90248-u
Winocur, G., Johnston, I., & Castel, H. (2018). Chemotherapy and cognition: International cognition and cancer task force recommendations for harmonising preclinical research. Cancer Treatment Reviews, 69, 72–83. https://doi.org/10.1016/j.ctrv.2018.05.017
Wolff, A. C., Somerfield, M. R., Dowsett, M., Hammond, M. E. H., Hayes, D. F., McShane, L. M., Saphner, T. J., Spears, P. A., & Allison, K. H. (2023). Human epidermal growth factor receptor 2 testing in breast cancer: ASCO–College of American pathologists guideline update. Journal of Clinical Oncology, 41(22), 3867–3872. https://doi.org/10.1200/JCO.22.02864
World Health Organization. (2020). Cancer. http://www.who.int/cancer/en/
You, J., Guo, L., Huang, M., Shi, X., Lin, M., Guo, Z., Cao, Y., Sun, Y., Xu, Q., Qu, W., Liu, H., & Chen, J. (2019). The effect and mechanism of YH0618 granule on chemotherapy- induced hair loss in patients with breast cancer: Study protocol for a randomized, double-blind, multi-center clinical trial. Trials, 20(1), 719. https://doi.org/10.1186/s13063-019-3893-3
