Modelos neuropsicobiológicos para estudo da dor e das emoções
DOI:
https://doi.org/10.34019/1982-1247.2020.v14.30596Palavras-chave:
Modelos animais, Dor, Comorbidades, Ansiedade, DepressãoResumo
Dor é uma experiência pessoal e subjetiva que pode apenas ser sentida pelo sofredor. A dor aguda tem a finalidade de avisar o indivíduo que algo está errado. Contudo, a dor crônica (DC) é um problema global de saúde, que afeta a qualidade de vida e torna o indivíduo parcial ou totalmente incapacitado. A pesquisa básica utiliza diversos modelos animais para o estudo da dor aguda ou crônica, bem como para o estudo das principais comorbidades oriundas de sua cronificação como a ansiedade e a depressão. Esta revisão aborda os modelos animais mais comumente utilizados neste contexto.
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Referências
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Steimer, T. (2011) Animal models of anxiety disorders in rats and mice: Some conceptual issues. Dialogues Clin Neurosci, 13, 495–506.
Steimer, T. (2002) The biology of fear- and anxiety-related behaviors, Les Laboratoires Servier.
Stein, D. J., & Bouwer, C. (1997) A neuro-evolutionary approach to the anxiety disorders, J Anxiety Disord. doi: 10.1016/s0887-6185(97)00019-4
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl) 85, 367–370. doi: 10.1007/BF00428203
Van Gaalen, M. M., & Steckler, T. (2000) Behavioural analysis of four mouse strains in an anxiety test battery. Behav Brain Res 115, 95–106. doi: 10.1016/s0166-4328(00)00240-0
Viana, M.B., Tomaz, C., & Graeff, F. G. (1994) The elevated T-maze: A new animal model of anxiety and memory. Pharmacol Biochem Behav 49, 549–554. doi: 10.1016/0091-3057(94)90067-1
Crawley, J., & Goodwin, F. K. (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 13, 167-170. doi: 10.1016/0091-3057(80)90067-2
Cryan, J. F., Hoyer, D., & Markou, A. (2003) Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents. Biol Psychiatry 54, 49–58. doi:10.1016/s0006-3223(02)01730-4
Cryan, J. F., & Sweeney, F., F. (2011) The age of anxiety: Role of animal models of anxiolytic action in drug discovery, John Wiley and Sons Inc. doi: 10.1111/j.1476-5381.2011.01362.x
File, S. E., & Hyde, J. R. G. (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62, 19–24. doi: 10.1111/j.1476-5381.1978.tb07001.x
File, S. E., & Wardill, A. G. (1975) Validity of head-dipping as a measure of exploration in a modified hole-
board. Psychopharmacologia 44, 53–59. doi: 10.1007/BF00421184
Garcia-Larrea. L., Magnin, M. (2008). Pathophysiology of neuropathic pain: review of experimental models and proposed mechanisms. Presse Med. 37,:315–340. doi: 10.1016/j.lpm.2007.07.025.
Handley, S. L., & Mithani, S. (1984) Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ’fear’-motivated behaviour. Naunyn Schmiedebergs Arch Pharmacol 327, 1–5. doi:10.1007/BF00504983
Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) Discovering endophenotypes for major depression, Neuropsychopharmacology. doi: 10.1038/sj.npp.1300506
Jaggi, A. S., Jain, V., Singh, N. (2011). Animal models of neuropathic pain. Fundam Clin Pharmacol. 2011, 25, 1-28. doi: 10.1111/j.1472-8206.2009.00801.x
Klein, D. F. (1974) Endogenomorphic Depression: A Conceptual and Terminological Revision. Arch Gen Psychiatry 31, 447–454. doi: 10.1001/archpsyc.1974.01760160005001
Krishnan, V., & Nestler, E. J. (2011) Animal models of depression: Molecular perspectives. Curr Top Behav Neurosci 7, 121–147. doi: 10.1007/7854_2010_108
Ledoux, J. E., Thompson, M. E., Iadecola, C., Tucker, L. W., & Reis, D. J. (1983) Local cerebral blood flow increases during auditory and emotional processing in the conscious rat. Science (80- ) 221, 576–578. doi: 10.1126/science.6867731
Levy, R., & Dubois, B. (2006) Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16, 916–928. doi: 10.1093/cercor/bhj043
Millan, M. J., & Brocco, M. (2003) The Vogel conflict test: Procedural aspects, γ-aminobutyric acid, glutamate and monoamines. Eur J Pharmacol, 463, 67–96. doi: 10.1016/s0014-2999(03)01275-5
Negus, S. S., Vanderah, T. W., Brandt, M. R., Bilsky, E. J., Becerra, L., Borsook, D. (2006) Preclinical assessment of candidate analgesic rugs: recent advances and future challenges. J Pharmacol Exp Ther, 319, 507–514. doi: 10.1124/jpet.106.106377
Nestler, E. J., & Hyman, S. E. (2010) Animal models of neuropsychiatric disorders, Nature Publishing Group. doi: 10.1038/nn.2647
Pellow, S., & File, S. E. (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat. Pharmacol Biochem Behav 24, 525–529. doi: : 10.1016/0091-3057(86)90552-6
Planchez, B., Surget, A., & Belzung, C. (2019) Animal models of major depression: drawbacks and challenges. Springer-Verlag Wien. doi: 10.1007/s00702-019-02084-y
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther, 229, 327–336. doi: 10.1016/0014-2999(78)90414-4
Rudy, J.W., Huff, N. C., & Matus-Amat, P. (2004) Understanding contextual fear conditioning: Insights from a two-process model. Neuroscience and Biobehavioral Reviews, 675–685. doi: 10.1016/j.neubiorev.2004.09.004
Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J., & Dourish, C. T. (1994) Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety. Psychopharmacology (Berl), 116, 56–64. doi: 10.1007/BF02244871
Steimer, T. (2011) Animal models of anxiety disorders in rats and mice: Some conceptual issues. Dialogues Clin Neurosci, 13, 495–506.
Steimer, T. (2002) The biology of fear- and anxiety-related behaviors, Les Laboratoires Servier.
Stein, D. J., & Bouwer, C. (1997) A neuro-evolutionary approach to the anxiety disorders, J Anxiety Disord. doi: 10.1016/s0887-6185(97)00019-4
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl) 85, 367–370. doi: 10.1007/BF00428203
Van Gaalen, M. M., & Steckler, T. (2000) Behavioural analysis of four mouse strains in an anxiety test battery. Behav Brain Res 115, 95–106. doi: 10.1016/s0166-4328(00)00240-0
Viana, M.B., Tomaz, C., & Graeff, F. G. (1994) The elevated T-maze: A new animal model of anxiety and memory. Pharmacol Biochem Behav 49, 549–554. doi: 10.1016/0091-3057(94)90067-1
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Publicado
2020-10-04
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Seção
Número Temático: Cérebro & Mente: Interações
