Glucose effects on the histomorfology of the peritoneum during peritoneal dialysis

Abstract

The peritoneum alterations in patients submitted to peritoneal dialysis for long periods begin with the mesothelium modifications and latter involves alterations of the submesothelium, fibrosis and vascular system. These alterations could be explained by the high concentration of glucose in the dialysis solution, and by other things. Therefore, the aim of this study was to study the histomorfological alterations of the peritoneal membrane in rats submitted to peritoneal dialysis, with the glucose solution at the local temperature. 20 Wistar rats were used, divided into two groups: control group (CG) with eight animals that didn’t receive intraperitoneal injection and the concentrated solution group (CSG) with 12 animals that received 10ml of the dialysis fluid with 4.25% of glucose once a day for 30 days. The visceral peritoneum of the spleen and the parietal peritoneum of the abdominal wall in the animals of CSG presented epithelial alterations with cubic transformation of the mesothelium cells and the thickness of the submesothelium layer, respectively. The dialysis solution of glucose at 4.25% in local temperature, done once a day, during 30 days, altered the histomorfology of the peritoneum.