Falls in hemodialysis patients: a 12 month prospective pilot study
DOI:
https://doi.org/10.34019/1982-8047.2021.v47.34069Keywords:
Accidental Falls, Renal Dialysis, Chronic Kidney FailureAbstract
Introduction: Complications caused by chronic kidney disease and hemodialysis (HD) increase the risk of falls. Objectives: The primary objective was to assess the incidence rate of falls over 12 months. The secondary objectives were to compare characteristics between patients with a history of falls and without a history of falls, and between fallers and recurrent fallers. Material and Methods: A 12 month longitudinal prospective pilot study was conducted with 43 patients on HD (54.9 ± 8.4 years; 58.1% male), assessed for physical function by the Mini Balance Evaluation Systems Test, Timed Up and Go, Gait Speed Measured over 4m (4-MGS) and 10-repetitions sit-to-stand test, and later, observed for 12 months. The incidence rate was provided in falls/person-year and comparisons between groups were performed by the Student's t-test, Mann-Whitney U test or Chi-square. Results: The incidence rate of falls was 0.27 (IC95%: 0.09–0.45) falls/person-year. Patients with a history of falls (n= 33) had a higher prevalence of hyperparathyroidism (p= 0.024) and lower gait speed compared to those without a history of falls (p= 0.007). Recurrent fallers patients (n= 5) were older (p = 0.043) and had a lower hemoglobin level (p= 0.032) compared to fallers. The 4-MGS had a sensitivity of 80% and specificity of 78.8% to discriminate patients with and without history of falls. Conclusion: The incidence rate of falls was 0.27 falls/person-year, and those with a history of falls have a higher prevalence of hyperparathyroidism and lower gait speed, and recurrent fallers are older and have a lower hemoglobin level. In addition, gait speed was able to discriminate patients with and without a history of falls.
Downloads
References
Abdel-Rahman EM, Turgut F, Turkmen K, Balogun RA. Falls in elderly hemodialysis patients. QJM. 2011; 104(10):829-38. doi: 10.1093/qjmed/hcr108
López-Soto PJ, De Giorgi A, Senno E, Tiseo R, Ferraresi A, Canella C et al. Renal disease and accidental falls: a review of published evidence. BMC Nephrol. 2015; 16:176. doi: 10.1186/s12882-015-0173-7
Cook WL, Tomlinson G, Donaldson M, Markowitz SN, Naglie G, Sobolev B et al. Falls and fall-related injuries in older dialysis patients. Clin J Am Soc Nephrol. 2006; 1(6):1197-204. doi: 10.2215/CJN.01650506
Farragher J, Rajan T, Chiu E, Ulutas O, Tomlinson G, Cook WL et al. Equivalent fall risk in elderly patients on hemodialysis and peritoneal dialysis. Perit Dial Int. 2016; 36(1):67-70. doi: 10.3747/pdi.2014.00163
Jácome C, Flores I, Martins F, Castro C, McPhee CC, Shepherd E et al. Validity, reliability and minimal detectable change of the balance evaluation systems test (BESTest), mini-BESTest and brief-BESTest in patients with end-stage renal disease. Disabil Rehabil. 2018; 40(26):3171-6. doi: 10.1080/09638288.2017.1375034
Lamb SE, Jørstad-Stein EC, Hauer K, Becker C. Development of a common outcome data set for fall injury prevention trials: the Prevention of Falls Network Europe Consensus. J Am Geriatr Soc. 2005; 53(9):1618-22. doi: 10.1111/j.1532-5415.2005.53455.x
Khow KSF, Visvanathan R. Falls in the aging population. Clin Geriatr Med. 2017; 33(3):357-68. doi: 10.1016/j.cger.2017.03.002
Kim J, Lee W, Lee SH. A systematic review of the guidelines and delphi study for the multifactorial fall risk assessment of community-dwelling elderly. Int J Environ Res Public Health. 2020; 17(17):6097. doi:10.3390/ijerph17176097.
Boyé NDA, Mattace-Raso FUS, Lieshout EMMV, Hartholt KA, Beeck EFV, Cammen TJMV. Physical performance and quality of life in single and recurrent fallers: data from the Improving Medication Prescribing to Reduce Risk of Falls study. Geriatr Gerontol Int. 2015; 15(3):350-5. doi: 10.1111/ggi.12287.
Immonen M, Haapea M, Similä H, Enwald H, Keränen N, Kangas M et al. Association between chronic diseases and falls among a sample of older people in Finland. BMC Geriatrics. 2020; 20:225. doi: 10.1186/s12877-020-01621-9
Desmet C, Beguin C, Swine C, Jadoul M, Université Catholique de Louvain Collaborative Group. Falls in hemodialysis patients: prospective study of incidence, risk factors, and complications. Am J Kidney Dis. 2005; 45(1):148-53. doi: 10.1053/j.ajkd.2004.09.027
Van Loon IN, Joosten H, Iyasere O, Johansson L, Hamaker ME, Brown EA. The prevalence and impact of falls in elderly dialysis patients Frail elderly Patient Outcomes on Dialysis (FEPOD) study. Arch Gerontol Geriatr. 2019; 83:285-91. doi: 10.1016/j.archger.2019.05.015
Abdel-Rahman EM, Yan G, Turgut F, Balogun RA. Long-term morbidity and mortality related to falls in hemodialysis patients: role of age and gender: a pilot study. Nephron Clin Pract. 2011; 118(3):c278-84. doi: 10.1159/000322275
Matsudo S, Araújo T, Matsudo V, Andrade D, Andrade E, Oliveira LC et al. Questionário Internacional de Atividade Física (IPAQ): estudo de validade e reprodutibilidade no Brasil. Rev Bras Ativ Fís Saúde. 2001; 6(2):5-18. doi:10.12820/rbafs.v.6n2p5-18
Franchignoni F, Horak F, Godi M, Nardone A, Giordano A. Using psychometric techniques to improve the balance evaluation systems test: the Mini-BESTest. J Rehabil Med. 2010; 42(4):323-31. doi: 10.2340/16501977-0537
Podsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991; 39(2):142-8. doi: 10.1111/j.1532-5415.1991.tb01616.x
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG et al. A Short Physical Performance Battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994; 49(2):M85-94. doi: 10.1093/geronj/49.2.m85
Csuka M, McCarty DJ. Simple method for measurement of lower extremity muscle strength. Am J Med. 1985; 78(1):77-81. doi: 10.1016/0002-9343(85)90465-6
Roberts R, Jeffrey C, Carlisle G, Brierley E. Prospective investigation of the incidence of falls, dizziness and syncope in haemodialysis patients. Int Urol Nephrol. 2007; 39(1):275-9. doi: 10.1007/s11255-006-9088-3
McAdams-DeMarco MA, Suresh S, Law A, Salter ML, Gimenez LF, Jaar BG et al. Frailty and falls among adult patients undergoing chronic hemodialysis: a prospective cohort study. BMC Nephrol. 2013; 14:224. doi: 10.1186/1471-2369-14-224
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013; 3: 1-150.
Abedi Yekta AH, Fatollahierad S, Hassabi M, Falaknazi K, Khosravi S, Poursaeed M. Fall incidence and risk factors in hemodialysis patients. Turk Neph Dial Transpl. 2016; 25(3):263-8. doi: 10.5262/tndt.2016.1003.08
Polinder-Bos HA, Emmelot-Vonk MH, Gansevoort RT, Diepenbroek A, Gaillard CA. High fall incidence and fracture rate in elderly dialysis patients. Neth J Med. 2014; 72(10):509-15.
Tran J, Ayers E, Verghese J, Abramowitz MK. Gait abnormalities and the risk of falls in CKD. Clin J Am Soc Nephrol. 2019; 14(7):983-93. doi: 10.2215/CJN.13871118
Carvalho TC, Dini AP. Risk of falls in people with chronic kidney disease and related factors. Rev Lat Am Enfermagem. 2020; 28:e3289. doi: 10.1590/1518-8345.3911.3289
Mokkink LB, Prinsen CAC, Patrick DL, Alonso J, Bouter LM, De Vet HCW et al. COSMIN methodology for systematic reviews of Patient Reported Outcome Measures (PROMs): user manual. 2018; 1-78.
Deandrea S, Lucenteforte E, Bravi F, Foschi R, Vecchia CL, Negri E. Risk factors for falls in community-dwelling older people: a systematic review and meta-analysis. Epidemiology. 2010; 21(5):658-68. doi: 10.1097/EDE.0b013e3181e89905
Fishbane S; Spinowitz B. Update on anemia in ESRD and earlier stages of CKD: Core Curriculum 2018. Am J Kidney Dis. 2018; 71(3):423-35. doi: 10.1053/j.ajkd.2017.09.026
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Luciana Angélica da Silva de Jesus, Leda Marília Fonseca Lucinda, Rafael Ferreira Cobucci , Henrique Barreto de Oliveira , Pedro Roberto Bacelar Rangel, Bernardo Cardoso Batista de Oliveira, Gabriel Ribeiro Pereira , Maycon Moura Reboredo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Cessão de Primeira Publicação à HU Revista
Os autores mantém todos os direitos autorais sobre a publicação, sem restrições, e concedem à HU Revista o direito de primeira publicação, com o trabalho licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento irrestrito do trabalho, com reconhecimento da autoria e crédito pela citação de publicação inicial nesta revista, referenciando inclusive seu DOI.