Experimental models of obesity: critical analysis of the metabolic profile and of aplicability

Authors

  • Barbara Bruna Abreu Castro Universidade Federal de Juiz de Fora (UFJF). http://orcid.org/0000-0002-5224-677X
  • Kaique Arriel Universidade Federal de Juiz de Fora (UFJF)
  • Petrus Renó Universidade Federal de Juiz de Fora (UFJF).
  • Hélady Sanders-Pinheiro Universidade Federal de Juiz de Fora (UFJF). http://orcid.org/0000-0001-8603-1331

DOI:

https://doi.org/10.34019/1982-8047.2018.v44.14053

Keywords:

Animal models, Metabolism, Obesity, Rodentia.

Abstract

Introduction: The prevalence of obesity and other related diseases is increasing worldwide worrisome. Characterized by increased body weight or excessive accumulation of body fat, obesity has been associated with increased mortality due to higher incidence of hypertension, diabetes and many types of cancer. Animal models provide key data for understanding the basic parameters that regulate the components of our energy balance. Objective: This review selected articles that used animal models (mice and mice) for obesity focusing on the main metabolic changes caused by obesity in order to present the main models used in the last 5 years. Material and Methods: Two searches were performed in the PubMed database using the expressions "obesity" AND "metabolism" AND "animal model" AND "mice" and "obesity" AND "metabolism" AND "animal model" AND "rat". We selected the papers considered more relevant from the criteria: detailed description of the experimental model and analysis of the metabolic parameters of interest: weight, lipid profile and glycemic profile. Other references were used to better elucidate the models found and also those that were not mentioned, but we considered important for the understanding of the evolution of animal models of obesity. Results: Mouse was the most used species, the predominant gender was male, the rodent age ranged from neonates up to 44 weeks and the follow-up period reached up to 53 weeks. Obesity was confirmed by a significant weight gain and most studies showed alterations in lipid and glycemic metabolism. We found five groups of induction of obesity, but the majority of studies applied hiperlipidic diets, model which better mimics metabolic chances found in humans. Conclusion: Investigating the causes and effects of induced obesity in experimental models may provide a better understanding of the pathophysiology of obesity, creating new options for prevention and treatment.

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Author Biographies

Barbara Bruna Abreu Castro, Universidade Federal de Juiz de Fora (UFJF).

Graduada em Ciências Biológicas em 2011 no Centro de Ensino Superior de Juiz de Fora (CES/JF). Foi bolsista de iniciação científica (PIBIC) em 2009 na área de Melhoramento de Plantas no Laboratório de Genética Vegetal da Empresa Brasileira de Pesquisa Agropecuária (Embrapa Gado de Leite). Mestre pelo programa de Pós Graduação em Saúde da Universidade Federal de Juiz de Juiz de Fora (UFJF). Desenvolveu o projeto de mestrado no Centro de Biologia da Reprodução (CBR), integrante do Núcleo Interdisciplinar de Estudos em Animais de Laboratório (NIDEAL) atuando na linha de pesquisa, "Fisiopatologia das lesões renais, endócrinas e metabólicas" e do Núcleo de Estudos e Pesquisas em Nefrologia (NIEPEN) pela linha: "Mecanismos inflamatórios na patogênese da lesão renal crônica". Atualmente, aluna de doutorado desenvolvendo o projeto: "Avaliação da morfologia e função renais em camundongos uninefrectomizados alimentados com dieta hipercalórica".

Kaique Arriel, Universidade Federal de Juiz de Fora (UFJF)

Aluno do curso de medicina na Universidade Federal de Juiz de Fora (UFJF).

Petrus Renó, Universidade Federal de Juiz de Fora (UFJF).

Aluno de medicina na Universidade Federal de Juiz de Fora (UFJF).

Hélady Sanders-Pinheiro, Universidade Federal de Juiz de Fora (UFJF).

Possui graduação em Medicina pela Universidade Federal do Ceará (1990), mestrado em Medicina (Nefrologia) pela Universidade Federal de São Paulo (1996) e doutorado em Medicina (Nefrologia) pela Universidade Federal de São Paulo (2001). Atualmente é pós-doutoranda da Universidade Federal de São Paulo em colaboração com a Universidade de Basel, Suíça . É vice-coordenadora do Departamento de Transplante Renal da Associação Brasileira de Transplante de Órgãos (ABTO) e responsável pelo Serviço de Transplante Renal do Hospital Universitário da Universidade Federal de Juiz de Fora (UFJF). É professora associada 4 de Nefrologia da UFJF, orienta alunos de pós-graduação (mestrado e doutorado) no Programa de Pós-graduação em Saúde e em programas de iniciação científica e monitoria. Possui experiência na área de Medicina, com ênfase em Nefrologia, atuando principalmente nos seguintes temas: transplante renal, isquemia - reperfusão, insuficiência renal aguda, sobrevida e doença renal crônica. Foi Vice-presidente do Comitê de Ética em Utilização Animal da UFJF e membro do Comitê de Ética da Pós-graduação em Saúde da UFJF.

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2019-04-04

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Castro BBA, Arriel K, Renó P, Sanders-Pinheiro H. Experimental models of obesity: critical analysis of the metabolic profile and of aplicability. HU Rev [Internet]. 2019Apr.4 [cited 2024Nov.22];44(2):199-210. Available from: https://periodicos.ufjf.br/index.php/hurevista/article/view/14053

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Vol. 44 No. 2 (2018): Obesidade: da fisiopatologia ao tratamento

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Artigos de Revisão da Literatura

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