Papel da microbiota na modulação da homeostase dos hospedeiros: correlação entre micobioma intestinal e obesidade

Autores

  • Francis Moreira Borges Universidade Federal de Juiz de fora
  • Thais Oliveira de Paula Universidade Federal de Juiz de fora
  • Jacy Gameiro Universidade Federal de Juiz de fora
  • Vânia Lúcia da Silva Universidade Federal de Juiz de fora
  • Cláudio Galuppo Diniz Universidade Federal de Juiz de fora

Resumo

Os fungos apresentam papel importante na saúde humana, sendo componentes da microbiota humana de diversos sítios anatômicos como, por exemplo, pele, cavidade bucal, trato gastrintestinal e trato geniturinário. São também agentes etiológicos de várias infecções, desde micoses superficiais até sistêmicas. Os fungos participam na regulação do sistema imunológico, podendo promover o surgimento de alergias das vias aéreas superiores. Estão presentes na composição da microbiota intestinal, formando o micobioma. Portanto, seu papel no desenvolvimento da obesidade deve ser considerado, atuando tanto na modulação da resposta imune local quanto através de sua interação com os demais microrganismos da microbiota intestinal. Este trabalho tem como objetivo revisar aspectos da participação microbiana na etiopatogenia da obesidade e discutir a participação dos fungos no microbioma intestinal, sua relação com a obesidade e as perspectivas futuras, com a utilização de metodologias moleculares, para um melhor entendimento do papel dos fungos na microbiota intestinal na saúde e na doença.

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Biografia do Autor

Francis Moreira Borges, Universidade Federal de Juiz de fora

Doutoranda, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Thais Oliveira de Paula, Universidade Federal de Juiz de fora

Mestranda, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Jacy Gameiro, Universidade Federal de Juiz de fora

Prof. Adjunta, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Vânia Lúcia da Silva, Universidade Federal de Juiz de fora

Prof. Adjunta, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Cláudio Galuppo Diniz, Universidade Federal de Juiz de fora

Prof. Associado, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Referências

BACKHED F. et al. The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the United States of America, Washington, v. 101, n. 44, p. 15718–15723, 2004.

BERNHARD, F. et al. Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia. Berlin, v.56, p. 311-322, 2013.

BERNOTIENE E.; PALMER G.; GABAY C. The role of leptin in innate and adaptive immune responses. Arthritis research & therapy, London, v.8, p.217, 2006.

BERVOETS, L. et al. Differences in gut microbiota composition between obese and lean children: across-sectional study. Gut Pathogens, London, v.5, n. 10, p. 1-10, 2013.

BOSELLO O.; ZAMBONI M. Visceral obesity and metabolic syndrome. Obesity reviews : an official journal of the International Association for the Study of Obesity, Oxford, v. 1 p. 47-56, 2000.

BRANDT, K. G. et al. Importância da microflora intestinal. Pediatria. São Paulo, v. 28, n. 2, p.117-127, 2006.

BRASIL. Ministério da Saúde. Vigitel Brasil 2013. Vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico: estimativas sobre frequência e distribuição sociodemográfica de fatores de risco e proteção para doenças crônicas nas capitais dos 26 estados brasileiros e no distrito federal em 2013 (Série G. Estatística e Informação em Saúde). Brasília, p.1-120, 2014.

CABALLERO B. The global epidemic of obesity: an overview. Epidemiologic reviews, Baltimore, v. 29, p. 1-5. 2007.

CANI, P. D.; DELZENNE, N.M. The role of the gut microbiota in energy metabolism and metabolic disease. Current pharmaceutical design, Schiphol, v. 15, p. 1546-1558, 2009.

CHEN, Y. et al. Correlation between gastrointestinal fungi and varying degrees of chronic hepatitis B virus infection. Diagnostic Microbiology and Infectious Disease, New York v. 70, n. 4, p.492-498, agosto. 2011.

CUI, J. A. et al. The human mycobiome in health and disease. Genome Medicine, London, v.5, n.63, p.1-12, 2013.

DARDENNE M. et al. Growth hormone modulates migration of developing T cells. Annals of the New York Academy of Sciences, New York,v. 1153, p. 1-5, 2009.

DELZENNE, N. M.; CANI, P. D. Interation between obesity and the gut microbiota: relevance in nutrition. Annual review of nutrition, Palo Alto, v. 31, p. 15-31, 2011

DIBAISE, J.K. et al.Gut Microbiota and Its Possible Relationship with Obesity. Mayo Clinic Proceedings, Oxford, v.83, n.4, p.460-469, 2008.

DIXIT, V. D. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. Journal of Leukocyte Biology. New York, v.84, p.882-892, out. 2008.

DOLLIVE, S. et al. A tool kit for quantifying eukaryotic rRNA gene sequences from human microbiome samples. Genome Biology, London, v.13, p.1-13, 2012.

DOLLIVE, S. et al. Fungi of the Murine Gut: Episodic Variation and Proliferation during Antibiotic Treatment. PloS One, San Francisco, v.8, n. 8, p. 1-12, ago. 2013.

DUNCAN, S.H. et al. Human colonic microbiota associated with diet obesity and weight loss. Internationl journal of obesity, London, v. 32, p. 1720-1724, 2008.

EIKELBOOM, D.H. Filamentous organisms observed in activated sludge. Water Research, Oxford, v. 9, p. 365-388, 1975.

EVERARD, A.; CANI, P.D. Diabetes, obesity and gut microbiota. Best Practice & Research Clinical Gastroenterology, Amsterdam, v.27, p. 73-83, 2013.

FARÍAS, M. N. et al. Microbiota intestinal: rol in obesidad. Revista chilena de nutrición : órgano oficial de la Sociedad Chilena de Nutrición, Bromatología y Toxicología, Santiago.. v. 38, n. 2, 2011.

FLINT, H. J. Obesity and the gut microbiota. Journal of clinical gastroenterology, New York, v. 45, n. 3, p. 128-132, 2011.

FONTAINE K.R.; BAROFSKY I. Obesity and health-related quality of life. Obesity reviews : an official journal of the International Association for the Study of Obesity, Oxford, v. 2, p. 173-182, 2001.

GILBRIDE, K.A.; LEE, D.Y.; BEAUDETTE, L.A.. Molecular techniques in wastewater: Understanding microbial communities, detecting pathogens, and real-time process control. Journal of Microbiological Methods, Amsterdam, v. 66, p. 1-20, 2006.

GOUBA, n. et al. Eukaryote Culturomics of the Gut Reveals New Species. PLoS ONE, San Francisco, v.9, n.9, p.1-5, set. 2014.

HADDAD J.J.; SAADE N.E., SAFIEH-GARABEDIAN B. Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis. Journal of neuroimmunology, Amsterdam, v.133, p.1-19, 2002.

HAN, J. M.; Levings, M. K. Adipose Inflammation Immune Regulation in Obesity-Associated. The Journal of Immunology, Bethesda, v.191, p. 527-533, jul. 2013.

HOFFMANN, C. el al. Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents. PloS One, San Francisco, v.8, n. 6, p. 1-12, jun. 2013.

KIM, Y. et al. Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2. Cell Host and Microbes, Cambridge, v.15, n. 1, p. 95-102, jan. 2014.

LA CAVA A.; MATARESE G. The weight of leptin in immunity. Nature reviews. Immunology, London, v. 4, p. 371-379, 2004.

LAM Q.L.; LU L. Role of leptin in immunity. Cellular & molecular immunology, Beijing, v.4, p.1-13, 2007.

LEE Y.K.; MAZMANIAN S.K. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science, London, v. 330, n. 6012 p. 1768–1773, 2010.

LOOS R. J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature genetics, New York, v. 40, n. 6, p. 768–775, 2008.

MAZMANIAN, S. K. et al. An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System. Cell, Cambridge, v. 122, n. 1, p.107-118, jul. 2005.

MOKDAD A. H. et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. Jama, Chicago, v.289, p. 76-79, 2003.

MOLLER D. E.; KAUFMAN K. D. Metabolic Syndrome: A Clinical and Molecular Perspective. Annual Review of Medicine, Palo Alto, n. 56 p. 45, 2005.

MORALES, P. et al. La microbiota intestinal: Un nuevo actor en el desarrollo de la obesidade. Revista Médica de Chile, Santiago, v.138, n. 8 p.1020-1027, agosto, 2010.

MUSSO, G. et al. Obesity, diabetes and gut microbiota : The hygiene hypotheses expanded?. Diabetes care, New York, v. 33, n. 10, p. 2277-2284, 2010.

OGDEN C.L.; CARROLL M.D.; FLEGAL K.M. High body mass index for age among US children and adolescents, 2003-2006. Jama, Chicago, v. 299, p. 2401-2405, 2008.

PRENTICE, A. M. et al. The emerging epidemic of obesity in developing countries. International Journal of Epidemiology, London, v.35, p.93-99, 2006.

QIN J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature, London, v. 464, n.7285, p. 59–65, 2010.

SAHU A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Frontiers in neuroendocrinology, new York, v. 24, p. 225-253, 2003.

SCUPHAM, A. J. et al. Abundant and Diverse Fungal Microbiota in the Murine Intestine. Applied and Envirmonmental Microbiology, Washington, v.72, n. 1, p. 793–801, jan. 2006.

SIEGMUND, B. et al. Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis. European Journal of Immunology. Weinheim, v. 32, n. 2, p.552-560, fev. 2002.

SILVA, R. C. et al. Extracellular enolase of Candida albicans is involved in colonization of mammalian intestinal epithelium. Frontiers in Cellular and Infection Microbiology, Lausanne, v. 4, p. 2-9, 2014.

SPEAKMAN J. R. Obesity: the integrated roles of environment and genetics. The Journal of nutrition, Springfield, v. 134, p. 2090S-2105S, 2004.

SUEZ, J. et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, London, v.0, n.0, p.1-17, 2014.

TAGLIABUE, A.; ELLI, M. The role of gut microbiota in human obesity: recent findings and future perspectives. Nutrition, metabolism and cardiovascular diseases, Amsterdam, v. 23, p. 160-168, 2013.

TILG H.; KASER A. Gut microbiome, obesity, and metabolic dysfunction. The Journal of clinical investigation, New Haven, v. 121, n .6, p.2126–2132, 2011.

TORRES-FUENTES, C. et al. A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review. Nutritional Neuroscience, Boca Raton, v.0, n.0, p.1-18, 2013.

TRAYHURN, P.; WOOD, I. S.. Adipokines: inflammation and the pleiotropic role of white adipose tissue. British journal of nutrition, Cambridge, v. 92, p. 347-355, 2004.

TURNBAUGH P.J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, London, v. 444, n. 7122, p. 1027–1031, dez. 2006.

TURNBULL A.V.; RIVIER C.L. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiological reviews, Bethesda, v. 79, p. 1-71, 1999.

VAEL, C. et al. Intestinal microflora and body mass index during the first three years of life: an observational study. Gut Pathogens, London, v.3, n. 8, p. 1-7, 2011.

VELLOSO L.A.; SAVINO W.;MANSOUR E. Leptin action in the thymus. Annals of the New York Academy of Sciences, New York, v.1153 p. 29-34, 2009

VILLELA N.B. et al. Quality of life of obese patients submitted to bariatric surgery. Nutrición hospitalaria, Madrid, v.19, n. 6, p. 367-371, 2004.

WARD, D.M.; WELLER, R.; BATESON, M.M. 16S rRNA sequences reveal numerous uncultured microorganisms in a natural community. Nature, London, v. 345, p. 63-65, 1990.

WILLIAMS G. et al. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiology & behavior, Oxford, v. 74 p. 683-701, 2001.

WILLIAMS G.; HARROLD J. A.; CUTLER D. J. The hypothalamus and the regulation of energy homeostasis: lifting the lidon a black box. The Proceedings of the Nutrition Society, London, v. 59 p. 385-396, 2000.

ZHAO et al. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochemical and Biophysical Research Communications, San Diego, v.300, p.247-252, 2003.

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2015-08-20

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1.
Borges FM, de Paula TO, Gameiro J, da Silva VL, Diniz CG. Papel da microbiota na modulação da homeostase dos hospedeiros: correlação entre micobioma intestinal e obesidade. HU Rev [Internet]. 20º de agosto de 2015 [citado 7º de outubro de 2024];40(1 e 2). Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/2452

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