Papel da microbiota na modulação da homeostase dos hospedeiros: correlação entre micobioma intestinal e obesidade

Autores

  • Francis Moreira Borges Universidade Federal de Juiz de fora
  • Thais Oliveira de Paula Universidade Federal de Juiz de fora
  • Jacy Gameiro Universidade Federal de Juiz de fora
  • Vânia Lúcia da Silva Universidade Federal de Juiz de fora
  • Cláudio Galuppo Diniz Universidade Federal de Juiz de fora

Resumo

Os fungos apresentam papel importante na saúde humana, sendo componentes da microbiota humana de diversos sítios anatômicos como, por exemplo, pele, cavidade bucal, trato gastrintestinal e trato geniturinário. São também agentes etiológicos de várias infecções, desde micoses superficiais até sistêmicas. Os fungos participam na regulação do sistema imunológico, podendo promover o surgimento de alergias das vias aéreas superiores. Estão presentes na composição da microbiota intestinal, formando o micobioma. Portanto, seu papel no desenvolvimento da obesidade deve ser considerado, atuando tanto na modulação da resposta imune local quanto através de sua interação com os demais microrganismos da microbiota intestinal. Este trabalho tem como objetivo revisar aspectos da participação microbiana na etiopatogenia da obesidade e discutir a participação dos fungos no microbioma intestinal, sua relação com a obesidade e as perspectivas futuras, com a utilização de metodologias moleculares, para um melhor entendimento do papel dos fungos na microbiota intestinal na saúde e na doença.

Biografia do Autor

Francis Moreira Borges, Universidade Federal de Juiz de fora

Doutoranda, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Thais Oliveira de Paula, Universidade Federal de Juiz de fora

Mestranda, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Jacy Gameiro, Universidade Federal de Juiz de fora

Prof. Adjunta, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Vânia Lúcia da Silva, Universidade Federal de Juiz de fora

Prof. Adjunta, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

Cláudio Galuppo Diniz, Universidade Federal de Juiz de fora

Prof. Associado, Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Juiz de Fora

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2015-08-20

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Borges FM, de Paula TO, Gameiro J, da Silva VL, Diniz CG. Papel da microbiota na modulação da homeostase dos hospedeiros: correlação entre micobioma intestinal e obesidade. hu rev [Internet]. 20º de agosto de 2015 [citado 11º de abril de 2021];40(1 e 2). Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/2452

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