A dissolution test for acetaminophen, phenylephrine and carbinoxamine associated in two different combinations in tablets using high performance liquid chromatography

Autores

  • Carina de Almeida Bastos Universidade Federal de Juiz de Fora
  • Hudson Caetano Polonini Universidade Federal de Juiz de Fora
  • Nádia Rezende Barbosa Raposo Universidade Federal de Juiz de Fora
  • Marcos Antônio Fernandes Brandão Universidade Federal de Juiz de Fora
  • Marcone Augusto Leal de Oliveira Universidade Federal de Juiz de Fora

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Resumo

A dissolution test for analysis of acetaminophen and phenylephrine (CP1) and acetaminophen and carbinoxamine (CP2) in tablets was developed and validated. The dissolution medium employed for CP1 was potassium monobasic phosphate buffer (pH 5.8, 0.15 mol L-1) and for CP2 was purified water. The temperature of dissolution medium (volume 900 and 500 ml in CP1 and CP2 case, respectively) was set at 37.0  0.5oC and the rotation speed of the paddles was set at 100 rpm during 30 minutes. Standards and sample aliquots were diluted in dissolution medium until adequate concentration and filtered before injection in the chromatographic system.

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Biografia do Autor

Carina de Almeida Bastos, Universidade Federal de Juiz de Fora

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Publicado

2014-04-22

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1.
Bastos C de A, Polonini HC, Raposo NRB, Brandão MAF, Oliveira MAL de. A dissolution test for acetaminophen, phenylephrine and carbinoxamine associated in two different combinations in tablets using high performance liquid chromatography. HU Rev [Internet]. 22º de abril de 2014 [citado 25º de junho de 2024];38(3 e 4). Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/2010

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