Evaluation of the antipsoriatic potential of topical formulations containing Lacistema pubescens Mart. fractions: an in vivo study
DOI:
https://doi.org/10.34019/1982-8047.2024.v50.44371Keywords:
Pharmaceutical formulation, Imiquimod, Natural Products, Psoriasis.Abstract
Introduction Psoriasis is a chronic inflammatory and immune-mediated disease that affects approximately 125 million people worldwide. Immunosuppressive agents are widely used; however, they can cause local and systemic adverse effects. Thus, new effective antipsoriatic agents with less probability of adverse reactions are needed, including plant-based pharmaceutical formulations. Objectives To evaluate in vivo the antipsoriatic potential of topical formulations containing the hexane fraction (HLP) and a sitosterol enriched fraction (SLP) from Lacistema pubescens. Material and Methods The pharmaceutical formulations were prepared as creams containing HLP and SLP. The antipsoriatic activity of THE HLP and SLP creams were evaluated by the mouse tail test and by imiquimod-induced ear edema in mice. Results The mouse tail test revealed that HLP cream induced orthokeratosis and increased the epidermal thickness. The HLP cream also inhibit significantly the ear thickness and the inflammatory parameters in animals that were treated with IMQ. Conclusion L. pubescens showed therapeutic potential for psoriasis treatment.
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Copyright (c) 2024 Josiane Mello da Silva, Nícolas de Castro Campos Pinto, Renata de Freitas Mendes, Maria Christina Marques Nogueira Castañon, Elita Scio
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