Granulomatosis with polyangiitis: case report with oral involvement
DOI:
https://doi.org/10.34019/1982-8047.2020.v46.30171Keywords:
Granulomatosis with Polyangiitis, Vasculitis, Wegener`s granulomatosis;, Anti-neutrophil cytoplasmic antibodyAbstract
Introduction: Granulomatosis with polyangiitis (GPA) is described as a triad of lesions, consisting of necrotizing granuloma of the respiratory tract, small and medium-sized disseminated vasculitis and glomerulonephritis. It represents the most frequent of systemic vasculitis.Objective:Currently, there is a shortage of data related to the profile of these patients in the country, with their clinical and epidemiological manifestations. Thus, the case presented aims to contribute to possible other patients who are in the same situation through knowledge of this clinical manifestation and an attempt to approach the complications associated with the disease described.Case report:This report describes the oral involvement with the formation of a deep ulceration, leading to communication between the oral and nasal cavities. Conclusion:Given the above, we reinforce the importance of an early diagnosis, made by an interdisciplinary team, in order to institute appropriate therapy and provide the patient with a longer survival.
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Carnevale C, Aramcibia-Tagle D, Sarria-Echegary P, Til-Perez G, Barberant T. Head and neck manifestations of granulomatosis with polyangiitis: a retrospective analysis of 19 patients and review of the literature. Int Arch Otorhinolaryngol. 2019; 23(2):165-71.
Antunes T, Barbas CSV. Granulomatose de Wegener. J Bras Pneumol. 2005; 31:21-6.
Pontes CDN, Silva YJA, Maneschy RB, Moraes Júnior RF, Miranda MV, Holanda LS et al. Granulomatose de Wegener em paciente jovem: relato de caso. Revista Eletrônica Acervo Saúde. 2019; 19(supl):1-6.
Cuzzi T, Micaelo LF, Fernandes NC. Granulomatose de Wegener localizada. Med Cutan Iber Lat Am. 2004; 32(5):218-22.
Hoffman GS, Specks U. Antineutrophil cytoplasmic antibodies. Arthritis & Rheumatism. 1998; 41(9):1521-37.
Erickson V, Hwang P. Wegenerʼs granulomatosis: current trends in diagnosis and management. Curr Opin Otolaryngol Head Neck Surg. 2007; 15(3):170-6.
Cascaes VM, Cascaes APR, Marcondes LGC. Manifestações nasais na Granulomatose de Wegener: a importância do diagnóstico precoce. Braz J Otorhinolaryngol. 1999; 65:338-40.
Gubbels SP, Barkhuizen A, Hwang PH. Head and neck manifestations of Wegener's granulomatosis. Otolaryngologic Clin North Am. 2003; 36:685-705.
Fonseca FP, Benites BM, Ferrari A, Sachetto Z, Campos GV, Almeida OP et al. Gingival granulomatosis with polyangiitis (Wegener`s granulomatosis) as a primary manifestation of the disease. Aust Dent J. 2017; 62(1):102-6.
Rasmussen N. Management of the ear, nose, and throat manifestations of Wegener granulomatosis: an otorhinolaryngologist's perspective. Curr Opin Rheumatol. 2001; 13(1):3-11.
Grygiel-Górniak B, Limphaibool N, Perkowska K, Puszczewicz M. Clinical manifestations of granulomatosis with polyangiitis: key considerations and major features. 2018; 130(7):581-96.
Ângulo CM, Zornoza RG, Aguera SO, Aclén JC, Gay MAG. Manifestaciones otorrinolaringológicas en pacientes con granulomatosis de Wegener (granulomatosis con poliangeitis). Acta Otorrinolaringol Esp. 2012; 63:206-11.
Holle JU, Laudien M, Gross WL. Clinical manifestations and treatment of Wegener´s granulomatosis. Rheum Dis Clin North Am. 2010; 36(3):507-26.
Ponniah I, Shaheen A, Shankar KA, Kumaran MG. Wegener`s granulomatosis: the current understanding. Oral Surg Oral Med Oral Pathol Oral Radiol. 2005; 100(3):265-70.
Rajagopalan S. Serious infections in elderly patients with diabetes mellitus. Clin Infect Dis. 2005; 40:990-6.
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