Effect of fructose on the intestinal microbiota: a systematic review of randomized clinical trials

Effect of fructose on the intestinal microbiota


  • Letícia Lourenço da Silva Instituto Federal do Sudeste de Minas Gerais, Campus Barbacena https://orcid.org/0009-0001-8812-167X
  • Rayane Rodrigues Lopes Instituto Federal do Sudeste de Minas Gerais, Campus Barbacena https://orcid.org/0009-0002-9822-4514
  • Mariana Julião Guilarducci Faculdade de Saúde Pública, Universidade de São Paulo https://orcid.org/0000-0002-7217-5470
  • Olívia Gonçalves Leão Coelho Departamento de Nutrição e Saúde, Universidade Federal de Viçosa
  • Flávia Galvão Cândido Departamento de Nutrição e Saúde, Universidade Federal de Viçosa
  • Nathalia Sernizon Guimarães Faculdade Ciências Médicas de Minas Gerais https://orcid.org/0000-0002-0487-0500
  • Júnia Maria Geraldo Gomes Instituto Federal do Sudeste de Minas Gerais, Campus Barbacena https://orcid.org/0000-0002-9554-4419




Frutose, Microbiota Gastrointestinal, Interações entre Hospedeiro e Microrganismos, Inflamação


Introduction: Preclinical data suggest that at least part of the harmful effects of excessive fructose consumption are due to alterations in the intestinal microbiota, which may be associated with a number of metabolic diseases, such as diabetes mellitus, obesity, inflammatory bowel disease, metabolic syndrome, and non-alcoholic fatty liver disease. Objective: The aim of this systematic review is to evaluate the effects of fructose consumption on the human intestinal microbiota. Material and Methods: A systematic search was carried out in electronic databases: Medline, Embase, and Cochrane Library without restriction to a year of publication and language. Inclusion criteria were primary articles that evaluated the effect of fructose consumption on the human intestinal microbiota. Results: Five randomized clinical trials were included. It was observed that the composition of the human intestinal microbiota seems to be altered differently in response to fructose consumption at distinct sources and concentrations. Overall, fructose administration increased bacterial profile associated with inflammation, hepatic steatosis, butyrate production, and inhibition of microbial aerobic respiration in the ileum (Proteobacteria, Actinobacteria, Anaerostipes, and Faecalibacterium). The administration of fructose showed a negative correlation for Firmicutes and a positive correlation for Parabacteroides in relation to total cholesterol and LDL-c. However, studies had great methodological heterogeneity and presented high risk of bias. Conclusion: Fructose administration affects the composition of human intestinal microbiota. More studies are needed to reach definitive conclusions.


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Como Citar

Silva LL da, Lopes RR, Guilarducci MJ, Coelho OGL, Cândido FG, Guimarães NS, Gomes JMG. Effect of fructose on the intestinal microbiota: a systematic review of randomized clinical trials: Effect of fructose on the intestinal microbiota. HU Rev [Internet]. 14º de maio de 2024 [citado 24º de junho de 2024];50:1-11. Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/42991



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