Avaliação do efeito da quercetina em ratos Wistar com Síndrome Metabólica

Autores

  • Marcella Martins Terra Universidade Federal de Juiz de Fora
  • Hussen Machado Universidade Federal de Juiz de Fora
  • Hélady Sanders Pinheiro Universidade Federal de Juiz de Fora
  • Martha de Oliveira Guerra Universidade Federal de Juiz de Fora
  • Vera Maria Peters Universidade Federal de Juiz de Fora

DOI:

https://doi.org/10.34019/1982-8047.2018.v44.16955

Palavras-chave:

Síndrome metabólica, Obesidade, Quercetina

Resumo

Introdução: O tratamento da síndrome metabólica (SM) é um desafio, uma vez que terapias não medicamentosas são de difícil implementação e o tratamento farmacológico ideal não está totalmente estabelecido. Objetivo: Avaliar o efeito da quercetina na pressão arterial (PA), dislipidemia e acúmulo de gordura visceral em modelo experimental de SM induzida por dieta hiperlipídica. Métodos: Ratos Wistar receberam ração hiperlipídica a partir da quarta semana de vida, por 20 semanas. O grupo tratado recebeu quercetina a partir da oitava semana de vida. Avaliou-se semanalmente o peso corporal e a PA de cauda por pletismografia. Ao final do experimento foram realizados testes de perfil glicêmico e lipídico. Resultados: A administração de dieta hiperlipídica se associou ao desenvolvimento de SM, caracterizada por acúmulo central de gordura, hipertensão arterial, hiperglicemia e hipertrigliceridemia. A quercetina não apresentou eficácia no tratamento das comorbidades que compõem a SM. Conclusão: A administração crônica diária da quercetina em modelo experimental de SM induzida por dieta hiperlipídica não alterou de forma significante o perfil nutricional, metabólico e pressórico dos animais.

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Publicado

2019-04-04

Como Citar

1.
Terra MM, Machado H, Pinheiro HS, Guerra M de O, Peters VM. Avaliação do efeito da quercetina em ratos Wistar com Síndrome Metabólica. HU Rev [Internet]. 4º de abril de 2019 [citado 9º de novembro de 2024];44(2):149-55. Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/16955

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