Os desafios e facilitadores da implantação do Programa Antimicrobial Stewardship em hospitais: uma revisão da literatura

Luiza Bosqueiro; Roberta  de Oliveira Alves; Jéssica Daniel Martins da  Silva; Ariadne Sousa Albuquerque; Carla Speroni Ceron; Tiago Marques dos Reis

doi:10.34019/1809-8363.2026.v29.46349

Authors

Luiza Bosqueiro Universidade Federal de Alfenas (UNIFAL-MG) https://orcid.org/0009-0004-3311-1396
Roberta de Oliveira Alves https://orcid.org/0009-0000-1090-6808
Jéssica Daniel Martins da Silva Universidade Federal de Alfenas (UNIFAL-MG) https://orcid.org/0000-0003-3820-8205
Ariadne Sousa Albuquerque Universidade Federal do Paraná (UFPR) https://orcid.org/0000-0002-5070-7456
Carla Speroni Ceron Universidade Federal de Ouro Preto (UFOP) https://orcid.org/0000-0001-8882-5792
Tiago Marques dos Reis Universidade Federal de Alfenas (UNIFAL-MG) https://orcid.org/0000-0002-0789-0187

DOI:

https://doi.org/10.34019/1809-8363.2026.v29.46349

Keywords:

Antimicrobial Stewardship, Hospitals, Pharmacists, Infections, Health Services

Abstract

Objective: To describe the state of the art of Antimicrobial Stewardship Programs (ASP) worldwide, to identify the main facilitators and challenges to program implementation, and to understand the role of pharmacists in this process. Methods: This is a literature review. Searches were conducted in the PubMed, LILACS, and Scopus databases. The MeSH/DeCS descriptors “antimicrobial stewardship” and “hospital” were combined with the keywords “barriers” and “facilitators.” Study selection and data extraction were performed independently by researchers. Results: A total of 188 studies were identified, of which 41 were included. Lack of time and high workload were the main challenges reported for ASP implementation, while the use of technology was highlighted as the main facilitator. Corroborating these findings, pharmacists emerged as professionals frequently associated with program success due to their expertise in medications. Conclusion: The main facilitators and challenges identified in the implementation of hospital-based ASPs involve human resource management and investment in technology. Pharmacists play a relevant role in program management.

KEYWORDS: Antimicrobial Stewardship. Hospitals. Pharmacists. Infections. Health Services.

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Author Biographies

Luiza Bosqueiro, Universidade Federal de Alfenas (UNIFAL-MG)

Graduada em Farmácia pela Universidade Federal de Alfenas (UNIFAL-MG). CV: http://lattes.cnpq.br/6757026484782815

Jéssica Daniel Martins da Silva, Universidade Federal de Alfenas (UNIFAL-MG)

Mestra em Ciências Farmacêuticas pela Universidade Federal de Alfenas (UNIFAL-MG). CV: http://lattes.cnpq.br/2231644595381919

Ariadne Sousa Albuquerque, Universidade Federal do Paraná (UFPR)

Mestra em Farmácia pela Universidade Federal do Paraná (UFPR). CV: http://lattes.cnpq.br/1206130375042448

Carla Speroni Ceron, Universidade Federal de Ouro Preto (UFOP)

Doutora em Ciências Biológicas (Farmacologia) pela Universidade de São Paulo (USP). Professora da Universidade Federal de Ouro Preto (UFOP). CV: http://lattes.cnpq.br/5937662509987802

Tiago Marques dos Reis, Universidade Federal de Alfenas (UNIFAL-MG)

Doutor em Ciências Universidade de São Paulo (USP). Professor Adjunto na Universidade Federal de Alfenas (UNIFAL-MG). CV: http://lattes.cnpq.br/8953945087467294