Biometric analysis and kidney morphologic of rats submitted to gestational protein restriction

Authors

  • Ariana Lobato Chaves
  • Rodrigo Neto Ferreira
  • Vinícius Novaes Rocha
  • Veronica Clemente Villar Martini

Keywords:

Hypertension. Nephropathy. Protein Restriction. Pregnancy. Wistar Rats.

Abstract

Gestational protein restriction in rats is associated with development of chronic diseases like diabetes and hypertension
in adulthood. The aim of this study was to develop model in mice to develop hypertension by protein restriction during
pregnancy and assess similar relationship with low birth weight and renal morphology. We studied rats, male and
female, divided into control group and low protein to the following day of birth, 10 days, 3 and 6 months postnatal. The
restricted animals during pregnancy were born with body mass and renal volume smaller than the animals that had normal
protein diet during pregnancy, besides having kidney damage in adults what causes the development of hypertension.

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Published

2011-06-28

Issue

Section

Artigos