Nutrigenômica/nutrigenética na elucidação das doenças crônicas

Autores/as

  • Maria Anete Santana Valente Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
  • Maria Cristina de Albuquerque Barbosa Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
  • Cibele Velloso Rodrigues Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
  • Patrícia Aparecida Fontes Vieira Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
  • Meire de Oliveira Barbosa Universidade Federal de Viçosa – campus Rio Paranaíba

Palabras clave:

Nutrigenômica, Doenças crônicas, Genes, Nutrientes

Resumen

A Nutrição contemporânea está centrada em pesquisas visando a promoção da saúde e a prevenção de doenças. A nutrigenômica e a nutrigenética tornam possível o estudo das interações entre dieta, nutrientes e genes. Esse artigo teve como objetivo identificar as interações entre os fatores genéticos e os fatores ambientais na etiologia das doenças crônicas como obesidade, doença celíaca, diabetes mellitus tipo 2, desordens cardiovasculares e câncer. Para utilização da nutrigenômica/nutrigenética como ferramenta para terapia nutricional são essenciais mais pesquisas básicas, estudos epidemiológicos e estudos de intervenção para entender como os nutrientes modulam in vivo os mecanismos das doenças crônicas. 

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Maria Anete Santana Valente, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177

Departamento de Nutrição

Maria Cristina de Albuquerque Barbosa, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177

Departamento de Nutrição

Cibele Velloso Rodrigues, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177

Departamento Básico – Área da Saúde

Patrícia Aparecida Fontes Vieira, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177

Departamento de Nutrição

Meire de Oliveira Barbosa, Universidade Federal de Viçosa – campus Rio Paranaíba

Departamento de Nutrição

Citas

AGARWAL, R. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochemical Pharmacology, New York, v. 60, n.8, p.1051-1059, 2000.

ARDEKANI, A. M.; JABBARI, S. Nutrigenomics and cancer. Avicenna Journal of Medical Biotechnology, Tehran, v. 1, n.1 , p. 9, 2009.

AZORIN-ORTUNO, M., et al. Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention. Journal of Nutritional Biochemistry, Kentucky, v. 23, p. 829-837, 2012.

BACKHED F. Changes in intestinal microflora in obesity: cause or consequence? Journal of Pediatric Gastroenterology and Nutrition, Warsaw, v.48, p. 56- 57, 2009.

BÜCHNER, F.L. et al. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).Cancer Causes Control, Boston, v. 21, p. 357-371, 2010.

CALDER, P.C. Fatty acids and inflammation: the cutting edge between food and pharma. European Journal of Pharmacology, Utrecht, v. 668, p. 50-58, 2011.

CALDER, P.C., et al. Inflammatory disease processes and interactions with nutrition. Brazilian Journal of Nutrition, Campinas, v. 101, p. 1-45, 2009.

CAVE, M.C. et al.Obesity, inflammation, and thepotential application of pharmaconutrition. Nutrition in Clinical Practice, Dallas, v.23, p.16–34, 2008.

CECIL, J. et al. Obesity and eating behaviour in children and adolescents: contribution of common gene polymorphisms. International Review of Psychiatry, Abingdon, v.24, p. 200–210, 2012.

COOKE, M.S. et al. DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutation Research, USA, v. 574, n.1-2, p.58-66, 2005.

COOK-MILLS, J.M., McCARY, C.A. Isoforms of vitamin E differentially regulate inflammation. Endocrine, Metabolic and Immune Disorders – Drug Targets, Bari, v. 10, p. 348-366, 2010.

CURTI, M.L.R. et al. Associations of the TNF-alpha -308 G/A, IL6 -174 G/C and AdipoQ 45 T/G polymorphisms with inflammatory and metabolic responses to lifestyle intervention in Brazilians at high cardiometabolic risk. Diabetology & Metabolic Syndrome, London, v. 4, p. 49-58, 2012.

DAIMIEL, L.; VARGAS, T.; MOLINA,A. Nutritional genomics for the characterization of the effect of bioactive molecules in lipid metabolism and related pathways. Electrophoresis, Weinheim, v.33, p. 2266–2289, 2012.

DAVIS, C.D. Nutritional Interactions: Credentialing of molecular targets for cancer prevention. Experimental Biology and Medicine, Shangai, v. 232, n. 2, p.176-183, 2007.

DAVIS, C.D; MILNER, J.A. Diet and cancer prevention. In: TEMPLE, N.J. et al. Nutritional Health: Strategies for disease prevention. Totowa: Humana Press, New York, p.151-171, 2006 .

DE RE, V. et al. Do gliadin and tissue transglutaminase mediate PPAR downregulation in intestinal cells of patients with coeliac disease? Gut, London, v. 59, p. 1730-1731, 2010.

DE STEFANO, D.et al. Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma. European Journal of Pharmacology, Utrecht, v. 566, p. 192-199, 2007.

FENECH, M. et al. Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice. Journal of Nutrigenetics and Nutrigenomics, Boston, v.4, p. 69-89, 2011.

FERGUSON, L.R. Nutrigenomics: integrating genomics approaches into nutrition research. Molecular Diagnosis and Therapy, USA, v.10, p.101-108, 2006.

FERRETTI, G.et al. Celiac disease, inflammation and oxidative damage: a nutrigenetic approach. Nutrients, Basel, v.4, p. 243-257, 2012.

FRISCO, S.; CHOI, S.W. Gene-nutrient interactions in one carbon metabolism.Current Drug Metabolism, Cambridge, v.6, n. 1, p. 37-46, 2005.

FUJI, T. M. M.; MEDEIROS, R.; YAMADA, R. Nutrigenômica e nutrigenética: importantes conceitos para a ciência da nutrição. Nutrire, São Paulo, v. 35, n. 1, p. 149-166, 2010.

GARCIA-BAILO B. et al. Genetic variation in taste and its influence on food selection. Omics, Kerala, v. 13, p. 69-80, 2009.

GRAU, K.etal. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese. European International Journal of Obesity, USA, v. 33, p. 1227–1234, 2009.

HEYMAN, M., MENARD, S. Pathways of gliadin transport in celiac disease. Annals of the New York Academy of Science, New York, v. 1165, p. 274-278, 2009.

HU, R.; KONG, A.N. Activation of MAP kinases, apoptosis and nutrigenomics of gene expression elicited by dietary cancer-prevention compounds. Nutrition, New York, v. 20, n.1, p. 83-88, 2004.

HUANG, J.; FROHLICH, J.; IGNASZEWSKI, A.P.The impact of dietary changes and dietary supplements on lipid profile. Canadian Journal of Cardiology, Montreal, v. 27, p. 488-505, 2011.

LEE, J.I. et al. Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prevention Research, Philadelphia, v. 2, p. 683-693, 2009.

LOOS, R.J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics, London, v. 40, p. 768–775, 2008.

LUCIANI, A.et al. S. Lysosomal accumulation of gliadin P31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPAR-downregulation in intestinal epithelial cells and celiac mucosa. Gut, London, v. 59, p. 311-319, 2010.

MAX, B.S.et al. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Human Molecular Genetics, Oxford, v.13, n. 19, p. 2197-2205, 2004.

MAMONE, G.et al. Proteomic analysis in allergy and intolerance to wheat products.Expert Reviews in Proteomics, London, v. 8, p. 95-115, 2011.

MANICKAM E, SINCLAIR AJ, CAMERON-SMITH D. Sup¬pressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes. Lipids in Health and Disease, USA, v. 9, p. 57, 2010.

MANSON, M.M. Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol. European Journal of Cancer, Villejuif, v. 41, n. 13, p. 1842-1853, 2005.

MARTIN, K.R. Targeting apoptosis with dietary bioactive agents. Experimental Biology and Medicine, London, v. 31, n. 2, p. 117-129, 2006.

MILLER, T.A.et al. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochemical And Biophysical Research Communication, Cambridge, USA, v. 336, n. 1, p. 309–315, 2005.

MIRANDA, T. B.; JONES, P. A. DNA methylation: the nuts and bolts of repression. Journal of Cellular Physiology, Burlington, v. 213, p. 384-390, 2007.

MOLLER, P.; LOFT, S. Interventions with anti oxidants and nutrients in relation to oxidative DNA damage and repair. Mutation Research, USA, v. 551, n. 1-2, p.79-89, 2004.

MUSAAD, S.; HAYNES, E. N. Biomarkers of Obesity and Subsequent Cardiovascular Events. Epidemiologic Reviews, Oxford, v. 29, p. 98–114, 2007.

MUTCH, D.M., WAHLI, W., WILLIAMSON, G. Nutrigenomics and Nutrigenetics: the emerging faces of nutrition. FASEB Journal, New York, v.19, p.1602-1616, 2005.

OKERE, I. C.et al. Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. American Journal of Physiology-Heart And Circulatory Physiology, Nebraska, v.291, n.1, p. H38-H44, 2006.

ORDOVAS, J. M., MOOSER, V. Nutrigenomics and nutrigenetics. Current Opinion Lipidology, Texas, v. 15, p.101-108, 2004.

ORTEGA-AZORÍN, C.et al. Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovascular Diabetology, Tel-Aviv, v.11, p. 137, 2012.

PENN, L. Assessment of dietary intake: NuGO symposium report. Genes Nutrition, Roma, v. 5, p. 205-213, 2010.

POLI, G. et al. Oxidative stress and cell signaling. Current Medicinal Chemistry, Cambridge, v. 11, n. 9, p. 1163-1182, 2004.

ROCHE, H.M.; PHILLIPS, C.; GIBNEY, M.J. The metabolic syndrome: the crossroads of diet and genetics. Proceedings of the Nutrition Society, Cambridge, v. 64, p. 371–377, 2005.

SALAS-SALVADÓ, J. et al.The role of diet in the prevention of type 2 diabetes. Nutrition, Metabolism & Cardiovascular Diseases, Napoli, v. 21, p. B32–B48, 2011.

SCHMID, P.M.; HEID, I.; BUECHLER, C. et al.Expression of fourteen novel obesity-related genes in Zucker diabetic fatty rats. Cardiovascular Diabetology, Tel-Aviv, v. 11, p. 48, 2012.

SCHUCH, J.B. et al. Nutrigenética: a interação entre hábitos alimentares e o perfil genético individual. Brazilian Journal of Biosciences, Porto Alegre, v. 8, n. 1, p. 73-84, 2010.

SHARMA S; KELLY TK; JONES PA: Epigenetics in cancer. Carcinogenesis, Oxford, v. 31, p. 27-36, 2010.

SHOELSON, S.E.; LEE, J.; GOLDFINE, A.B.Inflamation and insulin resistance. Journal of Clinical Investigation, North Carolina, v. 116, p.1793–1801, 2006.

SIMULA, M.P. et al. PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage. Molecular Medicine, New York, v. 16, p. 199-209, 2010.

SLYSKOVA, J. et al. Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity. DNA Repair, Amsterdam, v. 16C, p. 66-73., 2014

STEEVENS, J. et al. Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands cohort study. International Journal of Cancer, Germany, v. 129, n. 11, p. 2681-93, 2011.

STOJILJKOVIC, V.et al. Gluatathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 84, n. 1, p. 175-184, 2012.

STOJILJKOVIC, V. et al. Antioxidant status and lipid peroxidation in small intestinal mucosa of chidren with celiac disease. Clinical Biochemistry, Ontario, v. 42, p. 1431-1437, 2009.

SUDCHADA, P. et al. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Resource and Clinical Practice, Sydney, v. 98, p. 151-158, 2012.

SURH, Y.J. Cancer chemoprevention with dietary phytochemicals.Nature Reviews Cancer, London, v. 3, n. 10, p. 768-780, 2003.

SUZUKI, T., HARA, H. Role of flavonoids in intestinal tight junction regul ation. Journal of Nutritional Biochemistry, Kentucky, v. 22, p. 401-408, 2011.

TAI, E. S.et al. Polyunsaturated Fatty Acids Interact with the PPARA-L162V Polymorphism to Affect Plasma Triglyceride and Apolipoprotein C-III Concentrations in the Framingham Heart Study. The Journal of Nutrition, Houston, v. 135, p. 397–403, 2005.

TONJES, A. et al. Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. European Journal of Human Genetics, Netherlands, v. 18, p. 104–110, 2010.

VIEIRA, C. et al. Prevalence of celiac disease in children with epilepsy. Arquivos de Gastroenterologia, São Paulo, v. 50, n. 4, p. 290-296, 2013.

VINCENTINI, O. et al. Docosahexanoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. Clinical Nutrition, USA, v. 30, p. 541-546, 2011.

VOLKMAR, M. et al.; DNA methylationb profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. The EMBO Journal, London, v. 31, p. 1405–1426, 2012.

WEI, Y.; WANG. D.; PAGLIASSOTTI, M. Saturated fatty-acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Molecular and Cellular Biochemistry, Winnipeg, v. 303, n. 1, p. 105-113, 2007.

WEINSTEIN, I.B. Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. Carcinogenesis, Oxford, v.21, n.5, p. 857-864, 2000.

WIDIKER, S; KARST, S; WAGENER, A; et al. High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines. Journal of Applied Genetics, Poland, v. 51, p. 193–197, 2010.

WIESER, H., KOEHLER, P. The biochemical basis of celiac disease. Cereal Chemistry, Washington, v. 85, p. 1-13, 2008.

WILD, S.et al. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care, USA, v. 27, n. 5, p. 1047-53, 2004.

XIANG, N. et al. Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. Carcinogenesis, Oxford, v. 29, p. 2175-2181, 2008.

ZAPATA-GONZALEZ, F.et al. Human dendritic cell activities are modulated by the Omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. Journal of Leukocyte Biology, USA, v. 84, p. 1172-1182, 2008.

ZHANG, K,; KAUFMAN, R. J. The unfolded protein response: A stress signaling pathway critical for health and disease. Neurology, USA, v. 66, n. 1, p. 102-109, 2006.

ZHANG, P. et al. The GCN2 eIF2α kinase is required for adaptation to amino acid deprivation in mice. Molecular and Cellular Biology, Winnipeg, v. 22, n. 19, p. 6681-6688, 2002.

ZIMMER, K.P.et al. Endocytotic segregation of gliadin peptide 31-49 in enterocytes. Gut, London, v. 59, p. 300-310, 2010.

Publicado

2015-08-20

Cómo citar

1.
Valente MAS, Barbosa MC de A, Rodrigues CV, Vieira PAF, Barbosa M de O. Nutrigenômica/nutrigenética na elucidação das doenças crônicas. HU Rev [Internet]. 20 de agosto de 2015 [citado 21 de noviembre de 2024];40(3 e 4). Disponible en: https://periodicos.ufjf.br/index.php/hurevista/article/view/2479

Número

Sección

Artigos de Revisão da Literatura