Picossulfato de sódio comparado ao Manitol no preparo intestinal para colonoscopia: uma revisão sistemática
Série temática: Avaliação de Tecnologias em Saúde Hospitalar (ATS-H)
DOI:
https://doi.org/10.34019/1982-8047.2023.v49.43299Keywords:
Colonoscopy, Sodium Picosulfate, MannitolAbstract
Introduction: Colonoscopy is considered the gold standard test for diagnosing bowel cancer. The success of the exam, however, depends on effective colonic preparation. Objective: To evaluate the effectiveness of Sodium Picosulfate (PS) compared to Mannitol (MN) in intestinal preparation before colonoscopy examination. Methods: Systematic review of randomized controlled clinical trials (RCTs). The search for evidence in the scientific literature was conducted in the PubMed, Embase, Cochrane Library and Virtual Health Library databases by combining the following indexers and Boolean operators: “colonoscopy” AND "picosulfate sodium" AND "Mannitol". The risk of bias was assessed using the RoB 2.0 tool. Results: The effect of PS on colonic cleansing was similar or even lower than that demonstrated by MN. However, greater tolerability and palatability and a lower frequency of side effects associated with PS were observed compared to MN. The lack of methodological rigor of the included studies is highlighted, as 33% of these were classified as “high risk” of bias, while 66.7% presented “some concern”. Conclusion: Compared to MN, the use of PS does not promote a higher quality of colon cleansing, although it is related to the lower occurrence of side effects, greater tolerability and palatability. Therefore, it is suggested that the inclusion of PS must be considered only in patients with significant intolerance or the emergence of adverse effects that make preparation with MN unfeasible.
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Copyright (c) 2024 Priscila Weber, Juliano Boufleur Farinha, Cleiton da Gama Garcia, Roberto Flavio Gularte Martins, Christiane da Silva dos Santos, Leandro Farias Rodrigues
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