Effects of sodium alendronate on body weight, water and food intakes in adult female wistar rats.

Abstract

Aims Evaluate body weight, food and water intakes, of Wistar rats on alendronate. Methods Thirty rats, divided in 3 groups of 10. The first group (control group) received saline, the second and third ones receiving alendronate 4mg and alendronate 0.033mg, respectively (gavage). Body weight and food and water intakes were measured daily for 10 days. Results From the first to the last day the mean body weight ranged from 188,2g (SD 7,3) to 183,2g (SD 5,7) in group A, from 183,0g (SD 7,7) to (177,5g (SD 8,2) in group B, and from 188,9g (SD 17,1) to 184,5 (SD 16,4) in group C. Mean food intake ranged from 15,0g (SD 1,8) to 17,5g (SD 1,1) in group A, from 14,0g (SD 2,2) to 15,4g (SD 2,6) in group B, and from 23,3g (SD 2,0) to 14,9g (SD 2,6) in group C. Mean water intake ranged from 17,0ml (SD 6,5) to 20,6ml (SD 5,6) in group A, from 20,8ml (SD 1,3) to 22,1ml (SD 3,6) in group B, and from 16,0ml (SD 5,7) to 19,3ml (SD 2,7) in group C. Conclusions Alendronate caused significant difference in body weight (higher the dose lesser the weight) and water intake (control group consumed less water). No difference regarding food intake.