Association between oral lichen planus and hepatitis C: case report

Authors

  • Matheus Sampaio de Oliveira Faculdade de Odontologia, Universidade Federal de Juiz de Fora https://orcid.org/0000-0002-0414-6395
  • Pâmela Gomes Silva Faculdade de Odontologia, Universidade Federal de Juiz de Fora https://orcid.org/0000-0003-2469-330X
  • Yuri de Lima Medeiros Faculdade de Odontologia, Universidade Federal de Juiz de Fora https://orcid.org/0000-0002-4013-7752
  • Lauane Alves Rocha Faculdade de Odontologia, Universidade Federal de Juiz de Fora https://orcid.org/0000-0002-0090-4224
  • Eduardo Machado Vilela Departamento de Clínica Odontológica, Faculdade de Odontologia, Universidade Federal de Juiz de Fora

DOI:

https://doi.org/10.34019/1982-8047.2020.v46.30292

Keywords:

Lichen Planus, Hepatitis C, Oral Medicine

Abstract

Introduction: Hepatitis C (HCV) is a public health problem with silent symptoms. Its infection can develop with extrahepatic manifestations of an autoimmune character, due to the formation of immune complexes. One of these manifestations is oral lichen planus (OLP). Objective: Report a case of concomitance between OLP and HCV, demonstrating the importance of the dentist in detecting systemic diseases through oral repercussions. Case report: A 65-year-old female patient sought dental treatment with the main complaint of pain in the cheek mucosa lasting 3 months. On extraoral examination, jaundice was found in the eyes, while on intraoral examination, white lesions with a reticulated and striated aspect were detected in the cheek mucosa, bilaterally of approximately 1 cm on each side, diagnosed as OLP. Anemia and HCV were diagnosed through laboratory blood tests. Clobetasol propionate 0.05% was prescribed to treat oral lesions for mouthwash three times a day for 15 days, with complete remission of the lesions. The patient was referred for concomitant treatment with a hepatologist. Conclusion: It is important that, during the consultation, the dentist requests additional tests, such as the anti-HCV test, and investigates risk factors and signs suggestive of chronic liver diseases, especially in patients with OLP.

 

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References

Pramod GV, Deepashree PG, Sujatha GP. Malignant potential of oral lichen planus. J Med Radiol Pathol Surg. 2015; 1(6):22-5. doi: 10.15713/ins.jmrps.41

Xue JL, Fan MW, Wang SZ, Chen XM, Li Y, Wang L. A clinical study of 674 patients with oral lichen planus in China. J Oral Pathol Med. 2005; 34(8):467-72. doi: 10.1111/j.1600-0714.2005.00341.x

Grossmann SMC, Aguiar MCF, Teixeira R, Carmo MAV. Líquen plano bucal e Hepatite C. Arquivos em Odontologia. 2006; 42(1):47-56.

Mester A, Lucaciu O, Ciobanu L, Apostu D, Ilea A, Campian RS. Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP. Bosn J Basic Med Sci. 2018; 18(3):217-23. doi: 10.17305/bjbms.2018.3133

Kurago ZB. Etiology and pathogenesis of oral lichen planus: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122(1):72-80.

Ministério da Saúde (BR). Secretaria Executiva. Programa Nacional de Hepatites Virais. Hepatites Virais: o Brasil está atento. Brasília: Ministério da Saúde; 2003.

Rocha MR, Lins L, Cattony AC. Associação entre líquen plano e o vírus da hepatite C: um estudo de metanálise. Rev Port Estomatol Med Dent Cir Maxilofac. 2018; 59(1):2-9. doi: 10.24873/j.rpemd.2018.06.220

Halawani M. Hepatitis C virus genotypes among patients with lichen planus in the Kingdom of Saudi Arabia. Int J Dermatol. 2014; 53(2):171-7. doi: 10.1111/j.1365-4632.2012.05685.x

Mokni M, Rybojad M, Puppin D Jr, Catala S, Venezia F, Djian R et al. Lichen planus and hepatitis C virus. J Am Acad Dermatol. 1991; 24(5 Pt 1):792. doi: 10.1016/s0190-9622(08)80376-3

Nagao Y, Sata M. A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus. BMC Gastroenterol. 2012; 12:31. doi: 10.1186/1471-230X-12-31

Patil S, Khandelwal S, Rahman F, Kaswan S, Tipu S. Epidemiological relationship of oral lichen planus to hepatitis C virus in an Indian population. Oral Health Dent Manag. 2012; 11(4):199-205.

Lodi A, Pellicano R, Carrozzo. Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Oral Dis. 2010; 16(7):601-12.

Grossmann SMC, Aguiar MCF, Teixeira R, Carmo MAV. Oral lichen planus and chronic hepatitis c: a controversial association. Am J Clin Pathol. 2007; 127(5):800-4.

Alaizari NA, Al-Maweri SA, Al-Shamiri HM, Tarakji B, Shugaa-Addin B. Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis. Aust Dent J. 2016; 61(3):282-7. doi: 10.1111/adj.12382.

Georgescu SR, Tampa M, Mitran MI, Mitran CI, Sarbu MI, Nicolae I et al. Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection. Exp Ther Med. 2019;17(2):1045-51. doi: 10.3892/etm.2018.6987

Kurokawa M, Hidaka T, Sasaki H, Nishikata I, Morishita K, Setoyama M. Analysis of hepatitis C virus (HCV) RNA in the lesions of lichen planus in patients with chronic hepatitis C: detection of anti-genomic- as well as genomic-strand HCV RNAs in lichen planus lesions. J Dermatol Sci. 2003; 32(1):67-70. doi: 10.1016/S0923-1811(03)00049-5

Nagao Y, Sata M, Noguchi S, Seno'o T, Kinoshita M, Kameyama T et al. Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues. J Oral Pathol Med. 2000; 29(6):259-66. doi: 10.1034/j.1600-0714.2000.290604.x

Lucchese A. A potential peptide pathway from viruses to oral lichen planus. J Med Virol. 2015; 87(6):1060-5. doi: 10.1002/jmv.24131

Shi P, Liu W, Zhou ZT, He QB, Jiang WW. Podoplanin and ABCG2: malignant transformation risk markers for oral lichen planus. Cancer Epidemiol Biomarkers Prev. 2010; 19:844‑9.

García-Pola MJ, González-Álvarez L, Garcia-Martin JM. Treatment of oral lichen planus: systematic review and therapeutic guide. Med Clin (Barc). 2017; 149(8):351-62. doi: 10.1016/j.medcli.2017.06.024.

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Published

2020-09-24

How to Cite

1.
de Oliveira MS, Gomes Silva P, de Lima Medeiros Y, Alves Rocha L, Machado Vilela E. Association between oral lichen planus and hepatitis C: case report. HU Rev [Internet]. 2020Sep.24 [cited 2024Jul.17];46:1-6. Available from: https://periodicos.ufjf.br/index.php/hurevista/article/view/30292

Issue

Vol. 46 (2020)

Section

Relato de Caso

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