Analysis of Alzheimer's disease pathogenesis: narrative literature review

Authors

DOI:

https://doi.org/10.34019/1982-8047.2019.v45.25924

Keywords:

Alzheimer's Disease, Oxidative Stress, Immune System

Abstract

Introduction: The pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD), has been increasingly studied in numerous scientific studies. Objectives: The purpose of this review was to describe the contribution of factors such as oxidative stress and the netosis process for the pathogenesis of neurodegenerative diseases such as AD. Material and Methods: A non-systematic bibliographic review was carried out in the databases PubMed and Scielo with the following descriptors: Alzheimer + oxidative stress, Alzheimer + netosis and Alzheimer + inflammation, in national and international scientific journals from 2000 to 2018. At the end of the selection 26 articles were used in this review. Results: Several studies have demonstrated important components linked to neuroinflammation as key components for the understanding of neurological involvement caused by AD, such as oxidative stress, neutrophil and microglial inflammatory responses, vascular and blood-brain barrier changes. Conclusion: Due to these findings, it is necessary to continue and advance the understanding of the pathophysiology of AD as well as the search for effective therapeutic approaches for this disease.

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Author Biographies

Nathan Miranda Rodrigues, Universidade Federal de Viçosa

Acadêmico de Medicina pela Universidade Federal de Viçosa.

Taciana de Souza Bayão, Universidade Federal de Viçosa

Acadêmica de Medicina pela Universidade Federal de Viçosa.

Isadora Barbosa Thomaz, Universidade Federal de Viçosa

Acadêmica de Medicina pela Universidade Federal de Viçosa.

Silvia Almeida Cardoso, Universidade Federal de Viçosa

Professora adjunto da Universidade Federal de Viçosa, departamento de Enfermagem e Medicina (DEM-UFV). Pesquisadora na área de Imunologia e Bioquímica clínica, no laboratório de Bioquímica (DEM-UFV) e Imunoglicobiologia (DBG-UFV).

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Published

2020-02-14

How to Cite

1.
Miranda Rodrigues N, de Souza Bayão T, Barbosa Thomaz I, Almeida Cardoso S. Analysis of Alzheimer’s disease pathogenesis: narrative literature review. HU Rev [Internet]. 2020Feb.14 [cited 2024Dec.4];45(4):465-70. Available from: https://periodicos.ufjf.br/index.php/hurevista/article/view/25924

Issue

Vol. 45 No. 4 (2019)

Section

Artigos de Revisão da Literatura

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