Obesidade: uma abordagem inflamatória e microbiana

  • Diego da Silva Lutkemeyer Universidade de São Paulo, Faculdade de Medicina - São Paulo, SP
  • Mariana Abrantes do Amaral Universidade de São Paulo, Instituto de Ciências Biomédicas - São Paulo, SP
  • Nathalia Hiromi Ishida Assunção Universidade de São Paulo, Instituto de Ciências Biomédicas - São Paulo, SP
  • Nathália Franchon Marques Tejada Universidade de São Paulo, Faculdade de Medicina - São Paulo, SP
  • Niels Olsen Saraiva Camara Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Imunologia - São Paulo, SP
Palavras-chave: Imunologia, Obesidade, Inflamação, Microbiota

Resumo

A obesidade está intimamente ligada ao estado inflamatório, sendo considerada uma patologia metabólica complexa. Dietas hipercalóricas alteram a composição da microbiota intestinal, sendo a mudança da proporção de bactérias dos filos Bacteroidetes e Firmicutes uma das consequências mais conhecidas.  Essa mudança determina a produção de metabólitos específicos do sistema imune, induzindo estado inflamatório responsável pelo agravamento de uma série de doenças. A dieta hipercalórica representa um fator de risco para a obesidade e para o diabetes mellitus, doenças interligadas pelo conceito de lipotoxicidade, e o estado inflamatório também contribui para o aparecimento e para a progressão de doenças cardiovasculares. Com esse artigo, objetivamos estudar a obesidade pela perspectiva imunológica e microbiológica, abordando as consequências de dietas hipercalóricas sobre o estado inflamatório e a sobre a microbiota. Ademais, associar a mudança no microbioma a doenças prevalentes como o diabetes mellitus e as doenças cardiovasculares, apontando abordagens terapêuticas potenciais.

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Publicado
2019-04-04
Como Citar
Lutkemeyer, D. da S., do Amaral, M. A., Ishida Assunção, N. H., Marques Tejada, N. F., & Saraiva Camara, N. O. (2019). Obesidade: uma abordagem inflamatória e microbiana. HU Revista, 44(2), 221 - 229. Recuperado de https://periodicos.ufjf.br/index.php/hurevista/article/view/13963
Seção
Artigos de Revisão da Literatura